Published March 2020
- CBD used in combination with bacitracin (a topical antibiotic cream) resulted in a greater than 64 fold increase in the effectiveness of bacitracin against gram-positive bacteria such as Staphylococcus species, Listeria monocytogenes, and Enterococcus faecalis. All are common and potential deadly human pathogens (1).
- The addition of CBD to bacitracin had a synergistic effect which helped to more effectively kill drug-resistant bacteria strains (2).
- The findings of this study suggest that CBD is an effective “helper compound” for killing gram-positive bacteria (3).
- Because less antibiotic is needed to effectively treat infections when helper compounds like CBD are employed, the risk of developing antibiotic-resistant bacteria is decreased (4).
CBD Antibiotic Synergy
- To determine the synergistic antibiotic effects of bacitracin (BAC) and CBD, a time-kill assay was performed to test whether or not CBD actually increased the effectiveness of bacitracin (5).
- There was no synergistic effect for CBD and bacitracin against gram-negative bacterias such as Pseudomonas aeruginosa, Salmonella typhimurium, Klebsiella pneumoniae, and Escherichia coil.
- Difficulty treating drug-resistant bacteria such as Staphylococcus aureus has sparked a search for new antibiotic compounds and treatment strategies (6).
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Keywords: cannabidiol, antibiotics, antibacterial
Wassmann CS, Højrup P, Klitgaard JK. Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria. Sci Rep. 2020;10(1):4112. Published 2020 Mar 5. doi:10.1038/s41598-020-60952-0