graphic cannabidiol for super bugs (drug resistant bacteria strains) medical study summary

CBD Increases Antibiotic Effectiveness Against Staph And Listeria

This study summary provides fact-based answers about CBD antibacterial benefits.

  • see how CBD and antibiotics work together against drug-resistant Staph and Listeria bacteria
  • discover how CBD may rescue us from drug-resistant superbugs

If you don’t find an answer in this guide to a question you have, leave us a comment below. We’ll search the published studies to see if an answer exists and get back to you.

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CBD makes antibiotic 64 times more effective against drug-resistant Staph and Listeria bacteria. #cbd tell a friend


nih medical study

Published March 2020



CBD is a helper compound against gram positive bacteria


Study Results

  • CBD used in combination with bacitracin (a topical antibiotic cream) resulted in a greater than 64 fold increase in the effectiveness of bacitracin against gram-positive bacteria such as Staphylococcus species, Listeria monocytogenes, and Enterococcus faecalis.  All are common and potential deadly human pathogens (1).

cannabidiol antibacterial results 

  • The addition of CBD to bacitracin had a synergistic effect which helped to more effectively kill drug-resistant bacteria strains (2).

cbd skincare benefit



cbd makes antibiotic 64 times more effective against drug resistant bacteria


  • The findings of this study suggest that CBD is an effective “helper compound” for killing gram-positive bacteria (3).


  • Because less antibiotic is needed to effectively treat infections when helper compounds like CBD are employed, the risk of developing antibiotic-resistant bacteria is decreased (4).


cannabidiol antibiotic benefit

CBD Antibiotic Synergy

  • To determine the synergistic antibiotic effects of bacitracin (BAC) and CBD, a time-kill assay was performed to test whether or not CBD actually increased the effectiveness of bacitracin (5).


  • There was no synergistic effect for CBD and bacitracin against gram-negative bacterias such as Pseudomonas aeruginosaSalmonella typhimuriumKlebsiella pneumoniae, and Escherichia coil.                         



  • Difficulty treating drug-resistant bacteria such as Staphylococcus aureus has sparked a search for new antibiotic compounds and treatment strategies (6).

cbd antibiotic treatment



Ever brushed your teeth with CBD?  It’s more effective than Colgate and Oral B at killing the bacteria that cause plaque and tooth decay.  See the guide here.



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Keywords: cannabidiol, antibiotics, antibacterial



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