CBD Makes Antibiotic Effective Against Dangerous Pathogens

This is a scientific guide.

  • see how CBD and antibiotics work together against drug-resistant Staph and Listeria bacteria
  • discover how CBD may rescue us from drug-resistant superbugs

Let’s get started.

CBD makes antibiotic 64 times more effective against drug-resistant Staph and Listeria bacteria. #cbd tell a friend


nih medical study

Published March 2020


CBD is a helper compound against gram positive bacteria


Study Results

  • CBD used in combination with bacitracin (a topical antibiotic cream) resulted in a greater than 64 fold increase in the effectiveness of bacitracin against gram-positive bacteria such as Staphylococcus species, Listeria monocytogenes, and Enterococcus faecalis.  All are common and potential deadly human pathogens (1).                             

                                                                                                            cannabidiol antibacterial results 

  • The addition of CBD to bacitracin had a synergistic effect which helped to more effectively kill drug-resistant bacteria strains (2).

cbd skincare benefit



cbd makes antibiotic 64 times more effective against drug resistant bacteria


  • The findings of this study suggest that CBD is an effective “helper compound” for killing gram-positive bacteria (3).


  • Because less antibiotic is needed to effectively treat infections when helper compounds like CBD are employed, the risk of developing antibiotic-resistant bacteria is decreased (4).


cannabidiol antibiotic benefit

CBD Antibiotic Synergy

  • To determine the synergistic antibiotic effects of bacitracin (BAC) and CBD, a time-kill assay was performed to test whether or not CBD actually increased the effectiveness of bacitracin (5).


  • There was no synergistic effect for CBD and bacitracin against gram-negative bacterias such as Pseudomonas aeruginosaSalmonella typhimuriumKlebsiella pneumoniae, and Escherichia coil.                         



  • Difficulty treating drug-resistant bacteria such as Staphylococcus aureus has sparked a search for new antibiotic compounds and treatment strategies (6).

cbd antibiotic treatment


Ever brushed your teeth with CBD?  It’s more effective than Colgate and Oral B at killing the bacteria that cause plaque and tooth decay.  See the guide here.



Download The Study



Keywords: cannabidiol, antibiotics, antibacterial



Wassmann CS, Højrup P, Klitgaard JK. Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria. Sci Rep. 2020;10(1):4112. Published 2020 Mar 5. doi:10.1038/s41598-020-60952-0

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