CBD For Anxiety

 

This is a scientific guide.

Based on the latest medical studies.

Know the exact CBD benefits for:

  • Social Anxiety
  • Generalized Anxiety
  • Panic Attacks
  • PTSD

Let’s get started.

CBD Benefits: Anxiety

  • taking CBD shortly before simulated public speaking has a measurable anxiety benefit
  • acute administration of CBD helps reduce Parkinson’s tremors

Does a 300 mg dose of CBD reduce anxiety and tremors in Parkinson’s Disease?

nih cannabidiol anxiolytic

New CBD Research Published January 7, 2020

cbd study research results

Study Results: This clinical trial reports that a dose of 300mg cannabidiol decreased anxiety and tremors in patients with Parkinson’s Disease (1).

cannabidiol anxiety treatment

Study Method: Tested for multiple signs of anxiety and tremors during simulated public speaking in patients who had consumed a 300mg dose of CBD.

  • double-blind
  • randomized
  • placebo-controlled
  • crossover clinical trial

CBD medical study

Conclusion: the study showed statistically significant reductions in both anxiety and tremors during simulated public speaking in patients with Parkinson’s Disease who had taken oral CBD (2).

 

cannabidiol research 2019

By the numbers: 2 experimental sessions within a 15 day period were conducted on 24 individuals with Parkinson’s Disease.

Evaluation: After taking either a placebo or 300mg CBD, individuals underwent a Simulated Public Speaking Test (SPST) used to evaluate anti-anxiety medications.

Data were collected during the test for:

This data was assessed with repeated-measures analysis of variance (ANOVA) for CBD, the simulated public speaking phase and interactions between these variables.

Research conclusion: “acute CBD administration at a dose of 300 mg decreased anxiety in patients with [Parkinson’s Disease], and there was also decreased tremor amplitude” in a situation expected to produce anxiety such as public speaking (3).

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Study Authors:

 

de Faria SM

Department of Gerontology, Federal University of São Carlos

de Morais Fabrício D

Department of Psychology, Federal University of São Carlos

 

Tumas V

Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo

 

Castro PC

Department of Gerontology, Federal University of São Carlos

 

Ponti MA

Institute of Mathematical and Computer Sciences, University of São Paulo

 

Hallak JE

Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo

Zuardi AW 

Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo

 

Crippa JAS

Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo

 

Chagas MHN

Department of Gerontology, Federal University of São Carlos

 

Keywords: Cannabidiol; Parkinson’s disease; anxiety; tremor

References

de Faria SM, de Morais Fabrício D, Tumas V, et al. Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson’s disease. J Psychopharmacol. 2020;34(2):189–196. doi:10.1177/0269881119895536

CBD Benefits: Social Anxiety

Repeated CBD doses help teenagers with:

  • social anxiety disorder
  • avoidant personality disorder

300mg CBD oil dose helps Social Anxiety Disorder (SAD) symptoms in teenagers?

nih medical study

New CBD Research Published November 2019

  cbd research results

Study Results:  This double-blind placebo study of 37 teens reveals that a daily 300 mg dose of CBD oil significantly reduced social anxiety symptoms and avoidant personality disorder (1).

cannabidiol anxiety study

cannabidiol study results graph

Who benefits:  The purpose of this new CBD study was to assess the effect of cannabidiol on late Japanese teenagers with Social Anxiety Disorder (SAD) and avoidant personality disorder (2).

cannabidiol anxiety teenagers

By the numbers: This double-blind study was performed on thirty-seven 18-19-year-old teens diagnosed with Social Anxiety Disorder and avoidant personality disorder (3).

cannabidiol anxiety study

Study method: Cannabis oil containing a dose of 300mg CBD was given daily for a period of four weeks to 17 teenagers while a placebo was given to the remaining 20 teens.

cannabidiol anxiety benefit

Evaluation: Social anxiety disorder symptoms were measured at the beginning of the trial period and at the end using the Fear of Negative Evaluation Questionnaire and the Liebowitz Social Anxiety Scale.

Fear Of Negative Evaluation Questionnaire results showed an average 21.7% decrease over 4 weeks of cannabidiol treatment while the placebo group showed a decline of 0.8% on average (4).

cannabidiol anxiety therapy

social anxiety disorder

Fear of Negative Evaluation Questionnaire

The results were similar for the Liebowitz Social Anxiety Scale after 4 weeks of treatment with cannabidiol.  The average score of the CBD group improved by 16.3% while the placebo group (no CBD) reported improvements of only 4.6% (5).

social anxiety treatment

cannabidiol anxiety

Liebowitz Social Anxiety Scale

Both tests measure Social Anxiety Disorder symptoms in teenagers.

Conclusion: “CBD significantly decreased anxiety measured by both scales,” according to the study author (6).

cannabidiol SAD benefits
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Study Authors:

Masataka N

Primate Research Institute, Kyoto University, Inuyama, Japan

 

Keywords: avoidant personality disordercannabidiol; cannabinoid; cannabis; social anxiety disorder; social phobia; social withdrawal

References

Masataka N. Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders. Front Psychol. 2019;10:2466. Published 2019 Nov 8. doi:10.3389/fpsyg.2019.02466

Medical Cannabis For Anxiety

A scientific approach to identifying which cannabinoids and terpenes reduce or increase anxiety.

Medical Cannabis is rated 8.03/10 at reducing anxiety, according to patients.

 

nih medical study

CBD Research Published In December 2018

cbd research results 

Study ResultsMedical marijuana is an 8.03 on a scale of 0-10 (with 10 = extremely effective at treating anxiety), according to medical marijuana patients (1).

cannabidiol anxiety study

Important results: Medical marijuana that contained moderate levels of THC and the terpene trans-nerolidol was connected to decreased feelings of anxiety (2).

terpene anxiety study

Terpenes for Anxiety: Terpenes connected to an increase in anxiety were:

terpene anxiety study

cannabidiol study results graph

Our Summary:  This CBD study is an interesting survey of medical cannabis patients, strains and terpenes from a medical cannabis dispensary in Canada.

cannabidiol anxiety research

Survey results: Most patients rated medical cannabis as very beneficial in relieving symptoms of anxiety (3).

cannabidiol anxiety treatment

Increased anxiety: THC and some terpenes were connected with statistically significant increases in anxious feelings (4).

THC increases anxiety

Decreased anxiety: The following terpenes showed a statistically significant increase in anxious feelings:

cbd terpene anxiety

cbd anxiety treatment

Conclusion: Further research is needed to clearly explain “the entourage effects” that contribute to the anti-anxiety effects of specific strains of medical marijuana and hemp (5)

cannabidiol hemp study

 

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Study Authors:

Brishna S. Kamal

Whistler Therapeutics, Whistler, BC, Canada

Whistler Medical Marijuana, Whistler, BC, Canada

 

Fatima Kamal

Whistler Therapeutics, Whistler, BC, Canada

 

Daniel E. Lantela

Whistler Therapeutics, Whistler, BC, Canada

Whistler Medical Marijuana, Whistler, BC, Canada

Keywords: cannabinoids, terpenoids, THC, CBD, synergy, cannabis, anxiety, terpenes

References

Kamal BS, Kamal F, Lantela DE. Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype. Front Neurosci. 2018;12:730. Published 2018 Oct 22. doi:10.3389/fnins.2018.00730

CBD Benefits: SAD and Psychosis

This study focuses a critical eye on CBD’s overall benefits for anxiety and psychological disorders.

Does CBD help Social Anxiety Disorder (SAD) and Psychosis?

nih medical study

CBD Research Published August 2018

cbd research results

 

Study Results: A 2018 review of clinical CBD studies for psychiatric symptoms shows (1) :

  • may have antipsychotic effects in schizophrenia
  • may have substantial anti-anxiety effects in patients with Generalized Anxiety Disorder
  • possible reduction in withdrawal symptoms of cigarette smoking

cannabidiol study results graph

Our Summary:  This new CBD study published by Cambridge University Press is a review of the current medical literature on cannabidiol and its effects on mental health with specific regard to anxiety symptoms (2).

cbd anxiety study

Research findings:

  • CBD may have an anti-psychotic effect in people with schizophrenia by affecting the endocannabinoid system (3)                                                                                cannabidiol neurological disorders
  • CBD may have an anti-anxiety effect (acute) in people who struggle with a Social Anxiety Disorder (SAD)                     CBD anxiety benefit
  • CBD may reduce symptoms of withdrawal from quitting smoking of tobacco through the regulation of serotonin and glutamate—two compounds associated with depression (4).                                                                                                     cannabidiol tobacco withdrawal

 

Recommendations:

  • CBD needs to be studied further to confirm its effects in larger randomized clinical studies (5).     cannabidiol anxiety research         
  • Further study would allow researchers to connect specific CBD effects on patients to chemical reactions in the brain and nervous system (6).

 

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Check out this quick video on CBD for social anxiety and its benefits:

 

Study Authors:

G. M. Mandolini 

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan

 

M. Lazzaretti

Department of Neurosciences and Mental Health,Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,University of Milan

 

A. Pigoni 

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan

L. Oldani 

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan

G. Delvecchio 

Department of Pathophysiology and Transplantation, University of Milan

 

P. Brambilla 

Department of Pathophysiology and Transplantation, University of Milan

Keywords: Antianxiety agents; antipsychotics; clinical drug studies; drugs new; psychopharmacology

References

Mandolini GM, Lazzaretti M, Pigoni A, Oldani L, Delvecchio G, Brambilla P. Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview. Epidemiol Psychiatr Sci. 2018;27(4):327–335. doi:10.1017/S2045796018000239

CBD Benefits: Emotional Wellness

A deep scientific look at your endocannabinoid system, cannabinoids (CBD) and emotional balance.

Can CBD help your emotional wellness?

 

nih medical study

 

CBD Research Published November 2018

cbd study research results

 

Study Results: CBD has a complex relationship with your endocannabinoid system—the system that helps to maintain emotional balance (1).

cbd anxiety disorder

How it works: The endocannabinoid system helps to maintain emotional balance by regulating natural reward processes and moderating your natural response to stress (2).

cannabidiol emotional benefit

cannabidiol research 2019

 

Our Summary:  This is an interesting review of cannabinoids effects on emotions and the importance of the endocannabinoid system in mental health.

endocannabinoid mental health

According to this research, the endocannabinoid system (ECS) helps to balance emotional responses to rewarding and stressing events.

cannabidiol mental health

The ECS helps to regulate rewarding stimuli and moderate the physiological consequences of stress (3).

CBD helps to boost signaling in your ECS.

cannabidiol stress relief

Conclusion: This review confirms cannabidiol is a promising compound to help with anxiety and depression but is not regularly used in psychiatry because of a lack of clinical data and CBD dosage information (4).

CBD mental health

Extras:

  • in-depth information about the endocannabinoid system and its relationship with mental health (5).
  • the study explains how the endocannabinoid system plays a critical role in maintaining mood and emotional stability (6).

cannabidiol mood benefit

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Study Authors:

Mario Stampanoni Bassi

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy

 

Luana Gilio

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy

Laboratory of Synaptic Immunopathology, Department of Systems Medicine, Tor Vergata University

 

Pierpaolo Maffei 

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy

Ettore Dolcetti

Laboratory of Synaptic Immunopathology, Department of Systems Medicine, Tor Vergata University

Antonio Bruno

Laboratory of Synaptic Immunopathology, Department of Systems Medicine, Tor Vergata University

Fabio Buttari

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy

Diego Centonze

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy

Laboratory of Synaptic Immunopathology, Department of Systems Medicine, Tor Vergata University

Ennio Iezzi

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy

 

Keywords: endocannabinoids, reward, stress, depression, anxiety, multiple sclerosis, EAE, inflammation

References

Stampanoni Bassi M, Gilio L, Maffei P, et al. Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression. Front Mol Neurosci. 2018;11:424. Published 2018 Nov 20. doi:10.3389/fnmol.2018.00424

CBD Benefits: Panic Disorder

According to multiple studies, CBD is a promising treatment for panic disorder.

Does cannabidiol help Panic Disorder?

 

nih medical study

CBD Research Published February 2017

cbd research results

Study Results:

  • After reviewing multiple studies, CBD is a promising treatment for Panic Disorder (1)                                                                       cannabidiol anxiety study
  • More clinical studies need to be done to “clarify the specific mechanism of action of CBD and the safe and ideal therapeutic doses of this compound.”  (2)cannabidiol anxiety benefit

cannabidiol study results graph

 

Conventional treatment:

  • Panic Disorder affects approximately 5% of the worldwide population (3).                                                                                             panic disorder study
  • Common side effects and drug interactions of SSRIs (pharmaceutical drugs for panic disorder) cause many people to stop taking them.

cannabidiol anxiety study

Panic Disorder symptoms:

  • Sense of impending doom or danger
  • Fear of loss of control or death
  • Rapid, pounding heart rate
  • Sweating
  • Trembling or shaking
  • Shortness of breath or tightness in your throat
  • Chills
  • Hot flashes 

cannabidiol panic disorder effects

Off-label: Since CBD appears to have anti-anxiety effects, it has been recommended as a possible treatment for Panic Disorder (4).

cbd anxiety disorder

Conclusion:

  • After reviewing multiple clinical and preclinical trials, this study concludes that cannabidiol is a promising treatment for Panic Disorder (5).                                                                                                                                                                   CBD health benefit 
  • Specific future studies are needed to better understand how CBD helps anxiety and what the proper CBD dosage is for treating panic attacks.

cannabidiol anxiety benefit

 

 

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Study Authors:

Vanessa P. Soares

Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo

Alline C. Campos

Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo

 

Keywords: Animal models, cannabidiol, human studies, 5-HT1A receptors, panic disorder, serotonin

References

Soares VP, Campos AC. Evidences for the Anti-panic Actions of Cannabidiol. Curr Neuropharmacol. 2017;15(2):291–299. doi:10.2174/1570159×14666160509123955

CBD: Promising Anxiety Treatment

Scientific review of studies that laid the foundation for future research into CBD anxiety benefits.

nih medical study

CBD Research Published October 2015

Our Summary:  This research reviews multiple preclinical and clinical studies and finds substantial support for cannabidiol as a potential treatment for (1) :

  • generalized anxiety disorder (GAD)
  • panic disorder
  • social anxiety disorder (SAD)
  • obsessive-compulsive disorder
  • PTSD

cannabidiol mental health

Conclusion:

  • The review cautions that there is a lack of evidence regarding the effectiveness of CBD taken over long periods of time for anxiety disorders (2).                                                                                                                                                                            cannabidiol anxiety benefit
  • Further research is needed on the effects of taking cannabidiol for chronic anxiety disorders (3).

cannabidiol anxiety effects

 

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Check out this video about how CBD benefits for anxiety and depression:

Study Authors:

Esther M. Blessing

esther.blessing@nyumc.org

New York University School of Medicine

Maria M. Steenkamp

New York University School of Medicine

 

Jorge Manzanares

Instituto de Neurociencias de Alicante, Universidad Miguel Hernández and Consejo Superior de Investigaciones Científicas

 

Charles R. Marmar

New York University School of Medicine

Keywords: Cannabidiol, Endocannabinoids, Anxiety, Generalized anxiety disorder, Post-traumatic stress disorder

References

Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825–836. doi:10.1007/s13311-015-0387-1

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Preclinical CBD Anxiety Research

An early study established a basis for anti-anxiety and antidepressant-like effects of CBD.

Cannabidiol antidepressant and anti-anxiety effects in preclinical trials?

nih medical study

 

CBD Research Published in 2014

cbd research results 

Study Results:  This review of multiple studies found that CBD had “antidepressant-like and anti-anxiety-like effects” in animal models (1).

cannabidiol study results graph

Our Summary:  Anxiety and depression are illnesses that effect:

  • social life
  • productivity
  • health

cannabidiol anxiety study

CBD has anti-anxiety and anti-depressant effects in animal models (2).

cannabidiol anxiety study

Evaluation: After being administered CBD, animals were tested for:

  • forced swimming test (FST)
  • elevated plus maze (EPM)
  • Vogel conflict test (VCT)

mental health study

Conclusion:

  • The results of these tests showed CBD likely had antidepressant and anti-anxiety-like effects on animals (3).
  • Additionally, “most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.” (4)

CBD anxiety treatment

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Study Authors:

Alexandre R. de Mello Schier

alexschier@hotmail.com

Institute of Psychiatry – Federal University of Rio de Janeiro. Laboratory of Panic and Respiration

 

 

Keywords: Chronic Anxiety, Chronic Depression, Cannabidiol, anxiolytic-like, anxiety, cannabis Sativa, major depression

References

de Mello Schier AR, de Oliveira Ribeiro NP, Coutinho DS, et al. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS Neurol Disord Drug Targets. 2014;13(6):953–960. doi:10.2174/1871527313666140612114838

Cannabinoid Anxiety Research

A forward-looking early perspective on cannabinoids and their anxiety benefits.

 

Cannabinoids for anxiety disorders?

Research Results Say: Yes

nih medical study

CBD Research Published April 2012

cbd research results 

Study Results: 

  • CBD and cannabinoids have broad effects on emotions, anxiety and fear-related behaviors (1).                                               cannabidiol anxiety study results
  • THC may make anxiety and fear behavior worse with higher doses (2)CBD anxiety results
  • It appears that cannabidiol has chemical properties that reduce anxiety (3).                                                                                                                                  cannabidiol anxiety outcome
  • This research describes the reasons for the individualized effects of CBD and THC (4)     cannabidiol anxiety dosage

cannabidiol study results graph

Our Summary:  Medical cannabis appears to have both anxiety-causing and anxiety decreasing effects.  This study examines the effects of CBD and THC on anxiety and fear-related behaviors.

Variation in outcomes: Widely varying and individual anxiety responses to medical cannabis are caused by:

  • genetic factors
  • environmental factors
  • relative concentrations of THC to CBD
  • lesser cannabinoids present in the plant

The individualized response to medical cannabis for anxiety is a result of the complex network of interactions that occur in the cannabinoid system. (5)

Anxiety effects:

  • Some cannabinoids (like THC) can increase anxious feelings by activating the CB1 receptor while other cannabinoids (like CBD) can decrease anxiety by activating the CB2 receptor in the endocannabinoid system (6).
  • Additionally, the study describes genetic and environmental factors known to cause anxiety in some consumers of THC (7).

Conclusion: This study provides a good overview of knowledge about the effects of cannabinoids from herbal and synthetic sources as well as the effects of cannabinoids made by our own body as part of our endocannabinoid system (8).

 

 

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Study Authors:

Simone Tambaro

Dept. of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern California

Marco Bortolato

Dept. of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern California

 

Keywords: cannabis; anxiety; CB receptors; endocannabinoids; Δ9
-tetrahydrocannabinol; cannabidiol

References

Tambaro S, Bortolato M. Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent Pat CNS Drug Discov. 2012;7(1):25–40. doi:10.2174/157488912798842269

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