CBD For Anxiety
This is a scientific guide.
Based on the latest medical studies.
Know the exact CBD benefits for:
- Social Anxiety
- Generalized Anxiety
- Panic Attacks
Let’s get started.
2020 Medical Study Results
2019 Medical Study Results
2017 Medical Study Results
2015 Medical Study Results
2014 Medical Study Results
2012 Medical Study Results
CBD Benefits: Anxiety
- taking CBD shortly before simulated public speaking has a measurable anxiety benefit
- acute administration of CBD helps reduce Parkinson’s tremors
Does a 300 mg dose of CBD reduce anxiety and tremors in Parkinson’s Disease?
New CBD Research Published January 7, 2020
Study Results: This clinical trial reports that a dose of 300mg cannabidiol decreased anxiety and tremors in patients with Parkinson’s Disease (1).
Study Method: Tested for multiple signs of anxiety and tremors during simulated public speaking in patients who had consumed a 300mg dose of CBD.
- crossover clinical trial
Conclusion: the study showed statistically significant reductions in both anxiety and tremors during simulated public speaking in patients with Parkinson’s Disease who had taken oral CBD (2).
By the numbers: 2 experimental sessions within a 15 day period were conducted on 24 individuals with Parkinson’s Disease.
Evaluation: After taking either a placebo or 300mg CBD, individuals underwent a Simulated Public Speaking Test (SPST) used to evaluate anti-anxiety medications.
Data were collected during the test for:
- heart rate
- systemic blood pressure
- tremor frequency and amplitude
- Visual Analog Mood Scales (VAMS)
This data was assessed with repeated-measures analysis of variance (ANOVA) for CBD, the simulated public speaking phase and interactions between these variables.
Research conclusion: “acute CBD administration at a dose of 300 mg decreased anxiety in patients with [Parkinson’s Disease], and there was also decreased tremor amplitude” in a situation expected to produce anxiety such as public speaking (3).
Check out this quick video on Parkinson’s Disease and how it is effected by CBD and cannabis:
Keywords: Cannabidiol; Parkinson’s disease; anxiety; tremor
de Faria SM, de Morais Fabrício D, Tumas V, et al. Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson’s disease. J Psychopharmacol. 2020;34(2):189–196. doi:10.1177/0269881119895536
300mg CBD oil dose helps Social Anxiety Disorder (SAD) symptoms in teenagers?
New CBD Research Published November 2019
Study Results: This double-blind placebo study of 37 teens reveals that a daily 300 mg dose of CBD oil significantly reduced social anxiety symptoms and avoidant personality disorder (1).
Who benefits: The purpose of this new CBD study was to assess the effect of cannabidiol on late Japanese teenagers with Social Anxiety Disorder (SAD) and avoidant personality disorder (2).
By the numbers: This double-blind study was performed on thirty-seven 18-19-year-old teens diagnosed with Social Anxiety Disorder and avoidant personality disorder (3).
Study method: Cannabis oil containing a dose of 300mg CBD was given daily for a period of four weeks to 17 teenagers while a placebo was given to the remaining 20 teens.
Evaluation: Social anxiety disorder symptoms were measured at the beginning of the trial period and at the end using the Fear of Negative Evaluation Questionnaire and the Liebowitz Social Anxiety Scale.
Fear Of Negative Evaluation Questionnaire results showed an average 21.7% decrease over 4 weeks of cannabidiol treatment while the placebo group showed a decline of 0.8% on average (4).
The results were similar for the Liebowitz Social Anxiety Scale after 4 weeks of treatment with cannabidiol. The average score of the CBD group improved by 16.3% while the placebo group (no CBD) reported improvements of only 4.6% (5).
Both tests measure Social Anxiety Disorder symptoms in teenagers.
Conclusion: “CBD significantly decreased anxiety measured by both scales,” according to the study author (6).
Check out this quick video on CBD for anxiety symptoms:
Masataka N. Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders. Front Psychol. 2019;10:2466. Published 2019 Nov 8. doi:10.3389/fpsyg.2019.02466
Medical Cannabis For Anxiety
A scientific approach to identifying which cannabinoids and terpenes reduce or increase anxiety.
Medical Cannabis is rated 8.03/10 at reducing anxiety, according to patients.
CBD Research Published In December 2018
Study Results: Medical marijuana is an 8.03 on a scale of 0-10 (with 10 = extremely effective at treating anxiety), according to medical marijuana patients (1).
Important results: Medical marijuana that contained moderate levels of THC and the terpene trans-nerolidol was connected to decreased feelings of anxiety (2).
Terpenes for Anxiety: Terpenes connected to an increase in anxiety were:
Our Summary: This CBD study is an interesting survey of medical cannabis patients, strains and terpenes from a medical cannabis dispensary in Canada.
Survey results: Most patients rated medical cannabis as very beneficial in relieving symptoms of anxiety (3).
Increased anxiety: THC and some terpenes were connected with statistically significant increases in anxious feelings (4).
Decreased anxiety: The following terpenes showed a statistically significant increase in anxious feelings:
Conclusion: Further research is needed to clearly explain “the entourage effects” that contribute to the anti-anxiety effects of specific strains of medical marijuana and hemp (5).
Keywords: cannabinoids, terpenoids, THC, CBD, synergy, cannabis, anxiety, terpenes
Kamal BS, Kamal F, Lantela DE. Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype. Front Neurosci. 2018;12:730. Published 2018 Oct 22. doi:10.3389/fnins.2018.00730
CBD Benefits: SAD and Psychosis
This study focuses a critical eye on CBD’s overall benefits for anxiety and psychological disorders.
Does CBD help Social Anxiety Disorder (SAD) and Psychosis?
CBD Research Published August 2018
Study Results: A 2018 review of clinical CBD studies for psychiatric symptoms shows (1) :
- may have antipsychotic effects in schizophrenia
- may have substantial anti-anxiety effects in patients with Generalized Anxiety Disorder
- possible reduction in withdrawal symptoms of cigarette smoking
Our Summary: This new CBD study published by Cambridge University Press is a review of the current medical literature on cannabidiol and its effects on mental health with specific regard to anxiety symptoms (2).
- CBD may have an anti-psychotic effect in people with schizophrenia by affecting the endocannabinoid system (3)
- CBD may have an anti-anxiety effect (acute) in people who struggle with a Social Anxiety Disorder (SAD)
- CBD may reduce symptoms of withdrawal from quitting smoking of tobacco through the regulation of serotonin and glutamate—two compounds associated with depression (4).
- CBD needs to be studied further to confirm its effects in larger randomized clinical studies (5).
- Further study would allow researchers to connect specific CBD effects on patients to chemical reactions in the brain and nervous system (6).
Check out this quick video on CBD for social anxiety and its benefits:
Keywords: Antianxiety agents; antipsychotics; clinical drug studies; drugs new; psychopharmacology
Mandolini GM, Lazzaretti M, Pigoni A, Oldani L, Delvecchio G, Brambilla P. Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview. Epidemiol Psychiatr Sci. 2018;27(4):327–335. doi:10.1017/S2045796018000239
CBD Benefits: Emotional Wellness
A deep scientific look at your endocannabinoid system, cannabinoids (CBD) and emotional balance.
Can CBD help your emotional wellness?
CBD Research Published November 2018
Study Results: CBD has a complex relationship with your endocannabinoid system—the system that helps to maintain emotional balance (1).
How it works: The endocannabinoid system helps to maintain emotional balance by regulating natural reward processes and moderating your natural response to stress (2).
Our Summary: This is an interesting review of cannabinoids effects on emotions and the importance of the endocannabinoid system in mental health.
According to this research, the endocannabinoid system (ECS) helps to balance emotional responses to rewarding and stressing events.
The ECS helps to regulate rewarding stimuli and moderate the physiological consequences of stress (3).
CBD helps to boost signaling in your ECS.
Conclusion: This review confirms cannabidiol is a promising compound to help with anxiety and depression but is not regularly used in psychiatry because of a lack of clinical data and CBD dosage information (4).
- in-depth information about the endocannabinoid system and its relationship with mental health (5).
- the study explains how the endocannabinoid system plays a critical role in maintaining mood and emotional stability (6).
Check out this quick video about demystifying the endocannabinoid system (your body’s natural homeostasis system):
Keywords: endocannabinoids, reward, stress, depression, anxiety, multiple sclerosis, EAE, inflammation
Stampanoni Bassi M, Gilio L, Maffei P, et al. Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression. Front Mol Neurosci. 2018;11:424. Published 2018 Nov 20. doi:10.3389/fnmol.2018.00424
CBD Benefits: Panic Disorder
According to multiple studies, CBD is a promising treatment for panic disorder.
Does cannabidiol help Panic Disorder?
CBD Research Published February 2017
- After reviewing multiple studies, CBD is a promising treatment for Panic Disorder (1)
- More clinical studies need to be done to “clarify the specific mechanism of action of CBD and the safe and ideal therapeutic doses of this compound.” (2)
- Panic Disorder affects approximately 5% of the worldwide population (3).
- Common side effects and drug interactions of SSRIs (pharmaceutical drugs for panic disorder) cause many people to stop taking them.
Panic Disorder symptoms:
- Sense of impending doom or danger
- Fear of loss of control or death
- Rapid, pounding heart rate
- Trembling or shaking
- Shortness of breath or tightness in your throat
- Hot flashes
Off-label: Since CBD appears to have anti-anxiety effects, it has been recommended as a possible treatment for Panic Disorder (4).
- After reviewing multiple clinical and preclinical trials, this study concludes that cannabidiol is a promising treatment for Panic Disorder (5).
- Specific future studies are needed to better understand how CBD helps anxiety and what the proper CBD dosage is for treating panic attacks.
Check out this quick video about CBD benefits for anxiety:
Keywords: Animal models, cannabidiol, human studies, 5-HT1A receptors, panic disorder, serotonin
Soares VP, Campos AC. Evidences for the Anti-panic Actions of Cannabidiol. Curr Neuropharmacol. 2017;15(2):291–299. doi:10.2174/1570159×14666160509123955
CBD: Promising Anxiety Treatment
Scientific review of studies that laid the foundation for future research into CBD anxiety benefits.
CBD Research Published October 2015
Our Summary: This research reviews multiple preclinical and clinical studies and finds substantial support for cannabidiol as a potential treatment for (1) :
- generalized anxiety disorder (GAD)
- panic disorder
- social anxiety disorder (SAD)
- obsessive-compulsive disorder
- The review cautions that there is a lack of evidence regarding the effectiveness of CBD taken over long periods of time for anxiety disorders (2).
- Further research is needed on the effects of taking cannabidiol for chronic anxiety disorders (3).
Check out this video about how CBD benefits for anxiety and depression:
Keywords: Cannabidiol, Endocannabinoids, Anxiety, Generalized anxiety disorder, Post-traumatic stress disorder
Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825–836. doi:10.1007/s13311-015-0387-1
Preclinical CBD Anxiety Research
An early study established a basis for anti-anxiety and antidepressant-like effects of CBD.
Cannabidiol antidepressant and anti-anxiety effects in preclinical trials?
CBD Research Published in 2014
Study Results: This review of multiple studies found that CBD had “antidepressant-like and anti-anxiety-like effects” in animal models (1).
Our Summary: Anxiety and depression are illnesses that effect:
- social life
CBD has anti-anxiety and anti-depressant effects in animal models (2).
Evaluation: After being administered CBD, animals were tested for:
- forced swimming test (FST)
- elevated plus maze (EPM)
- Vogel conflict test (VCT)
- The results of these tests showed CBD likely had antidepressant and anti-anxiety-like effects on animals (3).
- Additionally, “most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.” (4)
Check out this video on CBD for depression.
de Mello Schier AR, de Oliveira Ribeiro NP, Coutinho DS, et al. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS Neurol Disord Drug Targets. 2014;13(6):953–960. doi:10.2174/1871527313666140612114838
Cannabinoid Anxiety Research
A forward-looking early perspective on cannabinoids and their anxiety benefits.
Cannabinoids for anxiety disorders?
Research Results Say: Yes
CBD Research Published April 2012
- CBD and cannabinoids have broad effects on emotions, anxiety and fear-related behaviors (1).
- THC may make anxiety and fear behavior worse with higher doses (2)
- It appears that cannabidiol has chemical properties that reduce anxiety (3).
- This research describes the reasons for the individualized effects of CBD and THC (4)
Our Summary: Medical cannabis appears to have both anxiety-causing and anxiety decreasing effects. This study examines the effects of CBD and THC on anxiety and fear-related behaviors.
Variation in outcomes: Widely varying and individual anxiety responses to medical cannabis are caused by:
- genetic factors
- environmental factors
- relative concentrations of THC to CBD
- lesser cannabinoids present in the plant
- Some cannabinoids (like THC) can increase anxious feelings by activating the CB1 receptor while other cannabinoids (like CBD) can decrease anxiety by activating the CB2 receptor in the endocannabinoid system (6).
- Additionally, the study describes genetic and environmental factors known to cause anxiety in some consumers of THC (7).
Conclusion: This study provides a good overview of knowledge about the effects of cannabinoids from herbal and synthetic sources as well as the effects of cannabinoids made by our own body as part of our endocannabinoid system (8).
Keywords: cannabis; anxiety; CB receptors; endocannabinoids; Δ9
Tambaro S, Bortolato M. Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent Pat CNS Drug Discov. 2012;7(1):25–40. doi:10.2174/157488912798842269