2019 Study: CBD may diminish ASD symptoms with increase in quality of life 4 patients, caretakers. #cbd #asd #autism tell a friend

 

 

cbd autism study nihPublished October 31, 2019

 

 

 

Study Results

 “The results reported here are very promising and indicate that CBD-enriched [cannabis extract] may [diminish] multiple ASD symptoms even in non-epileptic patients, with a substantial increase in life quality for both ASD patients and caretakers.” (1)

 

CBD autism treatment

 

 

 

 

 

 

Background

This new peer-reviewed CBD research for Autism Spectrum Disorder (ASD) was conducted because of mounting evidence “indicating the effectiveness of pure cannabidiol (CBD) and CBD-enriched Cannabis sativa extract (CE) for the treatment of autistic symptoms in refractory epilepsy patients.” (2)

CBD ASD benefit

Study Summary

This observational study concluding in October of 2019 reported that some symptoms of autism were also decreased significantly in patients who did not have epilepsy.

Participants

  • The study consisted of 18 patients.  3 of the 18 did not conclude the study due to the adverse effects of cannabis extract treatment. 
  • Of the 15 patients who continued taking the CBD treatment for the duration of the study, 10 were non-epileptic and 5 were epileptic.
  • Of the 15 patients who continued for the duration of the study, only one patient did not show improvement in autism symptoms.

CBD Dosage

The CBD extract administered had a CBD to THC ratio of 75:1. (3)

cannabidiol autism symptoms

Outcomes

After 6-9 months of treatment with CBD most patients showed some level of improvement in more than one category of autism symptoms: 

  • Attention-Deficit/Hyperactivity Disorder
  • Behavioral Disorders
  • Motor Deficits
  • Autonomy Deficits
  • Communication and Social Interaction Deficits
  • Cognitive Deficits
  • Sleep Disorders and Seizures (4)

cbd autism study

The most significant improvements were reported for:

  • Seizures
  • Attention-Deficit/Hyperactivity Disorder
  • Sleep Disorders
  • Communication and Social Interaction Deficits (5)

cannabidiol autism symptom improvement

Of the 10 non-epileptic patients with ASD, “nine of which presented improvement equal to or above 30% in at least one of the eight categories, six presented improvements of 30% or more in at least two categories and four presented improvements equal to or above 30% in at least four symptom categories.” (6)

10 out of the 15 patients in the study were using other medicines as well as CBD.  9 of the 10 were able to maintain improvements even after withdrawing from other medications. (7)

cannabidiol autism treatments

 

Adverse Effects

 Patients reported very infrequent or minimal adverse effects from the CBD treatment. (8)

CBD side effects

 

CBD autism effects

 

Conclusion

The study results state that “the results reported here are very promising and indicate that CBD-enriched [cannabis extract] may [diminish] multiple ASD symptoms even in non-epileptic patients, with a substantial increase in life quality for both ASD patients and caretakers.” (9)

 

CBD autism therapy

 

 

Download The CBD Research

 

 

Video: Family trying CBD for Autism.

 

Study Authors

Paulo Fleury-Teixeira

ePrimeCare Healthcare SA

 

Fabio Viegas Caixeta

Department of Physiological Sciences, University of Brasilia

 

Leandro Cruz Ramires da Silva

Clinical Hospital, Federal University of Minas Gerais

Associação Brasileira de Pacientes de Cannabis Medicinal

 

Joaquim Pereira Brasil-Neto

Department of Physiological Sciences, University of Brasilia

 

Renato Malcher-Lopes

Department of Physiological Sciences, University of Brasilia

 

 

Keywords: Cannabis sativa; autism spectrum disorders; cannabidiol; endocannabinoid system; epilepsy

References

Fleury-Teixeira P, Caixeta FV, Ramires da Silva LC, Brasil-Neto JP, Malcher-Lopes R. Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms: An Observational Study of 18 Participants Undergoing Compassionate Use. Front Neurol. 2019;10:1145. Published 2019 Oct 31. doi:10.3389/fneur.2019.01145

 

2019 Study: CBD Alters The Brain Regions Associated With Autism

 

 

2019 Study: CBD alters regions of the brain 'consistently implicated' in ASD . #cbd #asd #autism tell a friend

 

 

cbd autism treatment benefits

Published September 3, 2019

 

 

 

 

Study Results 

 

CBD alters regions of the brain “consistently implicated” in ASD.   According to the study authors, “Future studies should examine if this affects the complex behaviors these regions [regulate].” (1)

 

CBD autism effects

 

 

 

 

 

 

Summary

 

In this peer-reviewed study, the brains of 34 healthy men (half with ASD) were imaged using functional magnetic resonance imaging (fMRI). (2)

cannabidiol treatment results

CBD Dosage

  • Prior to the fMRI test, each was given either a 600mg oral CBD dose or a placebo.
  • The researchers were not aware of which subjects received the CBD and which received the placebo. (3)

 

cbd autism disorder

Evaluation

  • The fMRI tested for the ‘fractional amplitude of low-frequency fluctuations’ (fALFF) across the entire brain. 
  • In places where CBD altered the fALFF, the researchers also tested if ‘functional connectivity‘ between brain regions was altered. (4)

 

autism spectrum disorder

Outcomes

  • In the ASD group of patients, CBD significantly altered the fALFF in specific regions of the brain.  
  • In the ASD group only, CBD significantly altered some ‘functional connectivity’ between specific regions of the brain. (5)

 

CBD effects fmri

 

cannabidiol autism disorder

 

Conclusion

“Especially in ASD, CBD alters regional fALFF and ‘functional connectivity’ in/between regions consistently implicated in ASD. Future studies should examine if this affects the complex behaviors these regions [regulate].” (6)

CBD autism disorder

Video: Cannabinoids, CBD and the Autistic Spectrum.

 

 

Download The CBD Research

 

Study Authors

Pretzsch CM

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

Voinescu B

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

Mendez MA

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

Wichers R

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

Ajram L

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

Ivin G

South London and Maudsley NHS Foundation Trust Pharmacy

 

Heasman M

South London and Maudsley NHS Foundation Trust Pharmacy

 

Williams S

Department of Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

Murphy DG

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

Daly E

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

McAlonan GM

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

 

 

Keywords: Cannabidiol; Cannabis sativa; autism spectrum disorder; functional connectivity; low-frequency fluctuations

 

References

Pretzsch CM, Voinescu B, Mendez MA, et al. The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD). J Psychopharmacol. 2019;33(9):1141–1148. doi:10.1177/0269881119858306

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