cannabidiol reduces blood pressure in new 2020 medical study results title graphic

CBD Benefits Blood Pressure

According to a 2020 medical study published in the British Journal Of Clinical Pharmacology, CBD reduces blood pressure during rest and during periods of induced stress. After 7 days, participants in the study developed a tolerance for CBD.  Interestingly, CBD’s blood pressure benefit while at rest ceased once the tolerance was established but the blood pressure benefit under stressful conditions continued even after the tolerance for CBD was established.  

  • CBD reduces blood pressure at rest and during simulated stress
  • CBD’s ability to reduce blood pressure at rest ends after 7 days of treatment due to tolerance
  • CBD’s ability to reduce blood pressure under stressful conditions continues even after 7 days of treatment
  • CBD has significant vascular health benefits

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Published March 3, 2020

 

Study Results

  • A single oral dose of 600 mg CBD significantly reduced blood pressure at rest in a randomized, placebo‐controlled, double‐blind, parallel study.  However, this effect ended after 7 days of repeated dosing.  It is believed that accumulated tolerance to CBD is the cause.  (1)                                                                                                                                                CBD blood pressure study    
  • In the context of simulated stress, patients had lower blood pressure readings after being administered CBD.  Unlike the above short term benefits, this cardiovascular benefit was maintained even after 7 days of repeated CBD dosing.  (2)                      cannabidiol cardiovascular study      
  • For participants with vascular disease, 7-day treatment of CBD reduced artery stiffness and improved endothelial function (a cardiovascular disease risk factor). (3)                                                                                                                                cannabidiol cardiovascular benefit

 

Summary

  • Previous medical studies show that short-term administration of cannabidiol reduces blood pressure in men.
  • The goal of this study was to assess whether the long-term administration of cannabidiol reduced blood pressure in men.

 

Method

  • In a randomized, placebo-controlled, double-blind, parallel study 26 health men were given 600 mg CBD orally or placebo for seven days.
  • Cardiovascular parameters were assessed in participants at rest and during simulated stress after one CBD dose and after repeated CBD doses administered daily over 7 days.
  • Cardiovascular parameters were measured using Finometer, Vicorder and Duplex ultrasound.
Results After Single CBD 600 mg Oral Dose
  • Evaluated at rest: CBD reduced mean arterial pressure significantly (P = .04, two-way ANOVA, mean difference (MD) -2 mmHg, 95% CI -3.6 to -0.3)
  • Evaluated under simulated stress: Participants had lower systolic blood pressure (P = .001, two-way ANOVA, MD -6 mmHg, 95% CI -10 to -1)
Results after repeated CBD 600 mg Oral Dose
  • Evaluated at rest: CBD did not reduce mean arterial pressure after 7 days of dosing.
  • Evaluated under simulated stress: Participants had lower systolic blood pressure (P = .02, two-way ANOVA, MD -5.7 mmHg, 95% CI -10 to -1)
  • 7 days of CBD dosing increased internal carotid artery diameter (MD +0.55 mm, P = .01)
  • 7 days of CBD dosing reduced arterial stiffness by day 7 (pulse wave velocity; MD -0.44 m/s, P = .05)
  • 7 days of CBD dosing improved endothelial function (flow mediation dilatation, MD +3.5%, P = .02, n = 6 per group)

Conclusion

“CBD reduces BP at rest after a single dose but the effect is lost after seven days of treatment (tolerance); however, BP reduction during stress persists. The reduction in arterial stiffness and improvements in endothelial function after repeated CBD dosing are findings that warrant further investigation in populations with vascular diseases.”

 

How long does it take for CBD to reach peak concentration in your blood? How long does one dose of CBD last in your system?For CBD dosage studies, check out this guide.

 

 

Download The Study

 

Keywords: blood flow; blood pressure; cannabidiol; cardiovascular system; haemodynamics.

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