cannabidiol toothpaste

CBD Toothpaste

CBD has powerful antibacterial properties that may be beneficial in toothpaste. A 2020 medical study shows CBD and several other cannabinoids including CBG kill the bacteria that cause dental plaque and cavities better than leading toothpaste brands such as Oral B and Colgate. CBD may have significant dental pain relief benefits for sensitive teeth.

CBD Antibacterial Properties

CBD’s antibacterial properties and excellent safety profile make it a possible addition to popular toothpaste brands. CBD has been shown in several medical studies to have powerful CBD antibiotic effects against drug-resistant forms of Staph and Listeria bacteria. In fact, a 2019 study showed the addition of CBD made a first line antibiotic 64 times more effective.

CBD Oil Toothpaste

CBD oil is made by extracting CBD from hemp plants and then diluting it in an inert carrier oil, usually hemp oil or coconut oil. CBD oil toothpaste can be made at home. Several DIY recipes are available online with additional ingredients such as baking soda for stain removal or vitamins for remineralizing teeth.

CBD Toothpaste Medical Study

This medical study summarizes the benefits of CBD oil for toothpaste and dental care. Several CBD toothpaste products have been launched recently harnessing strong antibacterial CBD benefits for dental care. This study compares prominent cannabinoids such as CBD, CBG, and CBGA to popular synthetic toothpaste such as Oral B and Colgate.

nih medical study

chewing gum

CBD Toothpaste Study Results

In lab tests, CBD, CBC, CBN, CBG, and CBGA were found to be more effective at reducing plaque causing oral bacteria than either Oral B or Colgate (1). CBD is known to have antibacterial benefits against gram positive bacteria and drug resistant bacteria such as Staph and Listeria.

nih dental study

How does CBD Toothpaste work

Cannabinoids have antibacterial benefits that appear to be effective against dental plaque associated bacteria. (2) In fact, cannabinoids like CBD and CBG were found to be significantly more effective at reducing colony counts of plaque causing bacteria that lead to cavities than synthetic toothpaste like Colgate and Oral B.

nih medical study

nih medical study

Study Summary

CBD’s antibacterial properties were one of the first cannabinoid benefits described by medical studies. Recent studies have attempted to study whether or not these CBD antibiotic benefits extend to dental care.  This study tested how effective cannabinoids are at killing dental plaque-associated bacteria compared to common over the counter toothpaste products such as Oral B and Colgate (3).

cbd dental care

Study Method

  • 6 patient groups were created based on Dutch periodontal screening index
  • dental plaque samples were collected from 60 adults aged 18-45
  • samples were treated with either CBG, CBD, CBC, CBN, CBGA, “Cannabite-F”, “Oral B” or “Colgate”
  • samples were incubated to grow bacterial cultures
  • plaque-causing bacterial colonies were counted after the incubation period (4)

nih medical study

Study Evaluation

As you can see from the graph below, cannabinoids were more effective at reducing plaque-causing bacterial colonies than the synthetic oral care products Oral B and Colgate.

cannabinoids dental hygiene


“Cannabinoids have the potential to be used as an effective antibacterial agent against dental plaque-associated bacteria. Moreover, it provides a safer alternative for synthetic antibiotics to reduce the development of drug resistance.” (5)

Video on oral care and cannabis.

Download The CBD Research


Stahl V, Vasudevan K. Comparison of Efficacy of Cannabinoids versus Commercial Oral Care Products in Reducing Bacterial Content from Dental Plaque: A Preliminary Observation. Cureus. 2020;12(1):e6809. Published 2020 Jan 29. doi:10.7759/cureus.6809

Study Authors

Veronica Stahl

Dentistry, Euro Dent Belgium, Mortsel, BEL


 Kumar Vasudevan

Genetics, Cannibite, Antwerp, BEL

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