2019 Study: CBD Has Rapid And Sustained Antidepressant-like Effects
2019 Study: CBD has rapid and sustained antidepressant-like effects. #cbd #depression tell a friend
Published June 2019
Study Results
The results study did show that CBD had antidepressant-like effects within hours of being given to animal subjects. (1)
Background
- current pharmaceutical drugs have a substantial lag time before they become effective against depression.
- pharmaceutical drugs for depression have side effects which can cause people to stop taking them. (2)
Summary
The aim of the study is to test what CBD’s antidepressant effect is on animals and see if it has a quicker benefit than current pharmaceutical drugs used to treat depression. (3)
Conclusion
CBD antidepressant-like benefits persisted for the duration of the study. (4)
Interested in CBD benefits for anxiety disorders? Check out this guide to CBD for anxiety.
Check out this quick video about a young woman’s experience taking CBD for depression.
Study Authors:
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University Hospital
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University Hospital
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo
Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University Hospital
Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo
Keywords: Antidepressant; BDNF; Cannabidiol; Prefrontal cortex
References
Sales AJ, Fogaça MV, Sartim AG, et al. Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Mol Neurobiol. 2019;56(2):1070–1081. doi:10.1007/s12035-018-1143-4
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2018 Study: CBD Antidepressant-like Effects Depend On Serotonin Levels
2018 Study: CBD antidepressant-like effects are dependendant on brain serotonin levels . #cbd #depression tell a friend
Published August 2018
Study Results
CBD has antidepressant-like effects in animals but exactly how CBD causes these antidepressant effects is not yet understood. (1)
Summary
Study aims to begin the process of figuring out how CBD causes antidepressant-like effects—what is the particular mechanism at work. (2)
Conclusion
- CBD’s antidepressant-like effects are related to serotonin levels in the brain.
- This is not a conclusive study.
- This research moves our understanding forward as to how CBD may treat depression and exactly what mechanisms are at work in the brain to achieve CBD’s antidepressant effects. (3)
Download The CBD Research
Video: CBD oil for depression symptoms
Study Authors
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo
Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo
Keywords: Antidepressant; Cannabidiol; Desipramine; Fluoxetine; Noradrenaline; Serotonin
References
Sales AJ, Crestani CC, Guimarães FS, Joca SRL. Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:255–261. doi:10.1016/j.pnpbp.2018.06.002
2016 Study: CBD Induces Rapid Antidepressant-like Effect
2016 Study: CBD induces a rapid antidepressant-like effect. #cbd #depression tell a friend
Research Published 2016
Study Results
Researchers found that shortly after injections of CBD the serotonin and glutamate levels in the animals rose significantly which likely had an antidepressant effect in lab animals. (1)
Summary
This peer-reviewed study aims to understand more fully the mechanism by which CBD acts as an anti-depressant in animals. (2)
Conclusion
- This is not conclusive research but pushes the ball forward in our understanding of CBD anti-depressant effects. (3)
- Hopefully, this research and studies to follow will lead to a cannabidiol treatment for depression in the future. (4)
Download The CBD Research
Study Authors
Keywords: (−)Cannabidiol (PubChem CID: 12302390); 5-HT(1A) receptor; AM251 (PubChem CID: 2125); Antidepressant; Cannabidiol; Glutamate; Olfactory bulbectomy; Serotonin; WAY-100635 maleate salt (PubChem CID: 11957721)
References
Linge R, Jiménez-Sánchez L, Campa L, et al. Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors. Neuropharmacology. 2016;103:16–26. doi:10.1016/j.neuropharm.2015.12.017