2019 Study: CBD Has Rapid And Sustained Antidepressant-like Effects

2019 Study: CBD has rapid and sustained antidepressant-like effects. #cbd #depression tell a friend

 

cbd depression nih medical study

 Published  June 2019

 

 

 

Study Results

The results study did show that CBD had antidepressant-like effects within hours of being given to animal subjects. (1)

 

 

 

 

Background

  • current pharmaceutical drugs have a substantial lag time before they become effective against depression.
  • pharmaceutical drugs for depression have side effects which can cause people to stop taking them. (2)

 

cbd depression study

 

 

Summary

The aim of the study is to test what CBD’s antidepressant effect is on animals and see if it has a quicker benefit than current pharmaceutical drugs used to treat depression. (3)

 

 

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Conclusion

CBD antidepressant-like benefits persisted for the duration of the study. (4)

 

Interested in CBD benefits for anxiety disorders? Check out this guide to CBD for anxiety.

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Download The CBD Research

 

Check out this quick video about a young woman’s experience taking CBD for depression.

Study Authors:

Sales AJ

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo

Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo

 

Fogaça MV

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo

Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo

 

Sartim AG

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo

Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo

 

Pereira VS

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University Hospital

Wegener G

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University Hospital

 

Guimarães FS

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo

Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo

Joca SRL

samia@usp.br

Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University Hospital

Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo

 

Keywords: Antidepressant; BDNF; Cannabidiol; Prefrontal cortex

References

Sales AJ, Fogaça MV, Sartim AG, et al. Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Mol Neurobiol. 2019;56(2):1070–1081. doi:10.1007/s12035-018-1143-4

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2018 Study: CBD Antidepressant-like Effects Depend On Serotonin Levels

2018 Study: CBD antidepressant-like effects are dependendant on brain serotonin levels . #cbd #depression tell a friend

 

 

cbd depression benefits

Published August 2018

 

 

 

 

Study Results

CBD has antidepressant-like effects in animals but exactly how CBD causes these antidepressant effects is not yet understood. (1)

 

 

 

Summary

Study aims to begin the process of figuring out how CBD causes antidepressant-like effects—what is the particular mechanism at work. (2)

 

 

cbd nih antidepressant study

 

 

Conclusion

  • CBD’s antidepressant-like effects are related to serotonin levels in the brain.
  • This is not a conclusive study.
  • This research moves our understanding forward as to how CBD may treat depression and exactly what mechanisms are at work in the brain to achieve CBD’s antidepressant effects. (3)

cbd antidepressant medical study NIH

 

 

Download The CBD Research

Video: CBD oil for depression symptoms

Study Authors

Amanda J Sales

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo

Carlos C Crestani

Laboratory of Pharmacology, School of Pharmaceutical Sciences of Araraquara, São Paulo State University (UNESP)

Francisco S Guimarães

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo

 

Sâmia R L Joca

Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo

 

Keywords: Antidepressant; Cannabidiol; Desipramine; Fluoxetine; Noradrenaline; Serotonin

References

Sales AJ, Crestani CC, Guimarães FS, Joca SRL. Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:255–261. doi:10.1016/j.pnpbp.2018.06.002

2016 Study: CBD Induces Rapid Antidepressant-like Effect

2016 Study: CBD induces a rapid antidepressant-like effect. #cbd #depression tell a friend

 

 

cbd antidepressant medical study

Research Published 2016

 

 

 

 

Study Results

Researchers found that shortly after injections of CBD the serotonin and glutamate levels in the animals rose significantly which likely had an antidepressant effect in lab animals. (1)

 

 

cbd nih depression medical study

 

 

 

 

Summary

This peer-reviewed study aims to understand more fully the mechanism by which CBD acts as an anti-depressant in animals. (2)

 

cbd depression treatment

Conclusion

  • This is not conclusive research but pushes the ball forward in our understanding of CBD anti-depressant effects. (3)
  • Hopefully, this research and studies to follow will lead to a cannabidiol treatment for depression in the future. (4)

 

 

 

 

 

 

Download The CBD Research

Study Authors

Raquel Linge

Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (Universidad de Cantabria, CSIC, SODERCAN), Departamento de Fisiología y Farmacología, Universidad de Cantabria

 

Laura Jimenez

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Departamento de Neuroquímica y Neurofarmacología, Instituto de Investigaciones Biomédicas de Barcelona

 

Leticia Campa

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Departamento de Neuroquímica y Neurofarmacología, Instituto de Investigaciones Biomédicas de Barcelona

 

Fuen Pilar-Cuellar

Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (Universidad de Cantabria, CSIC, SODERCAN), Departamento de Fisiología y Farmacología, Universidad de Cantabria

 

Vidal R

Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (Universidad de Cantabria, CSIC, SODERCAN), Departamento de Fisiología y Farmacología, Universidad de Cantabria

 

Pazos A

Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (Universidad de Cantabria, CSIC, SODERCAN), Departamento de Fisiología y Farmacología, Universidad de Cantabria

 

Adell A

Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (Universidad de Cantabria, CSIC, SODERCAN), Departamento de Fisiología y Farmacología, Universidad de Cantabria

 

Díaz Á

Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (Universidad de Cantabria, CSIC, SODERCAN), Departamento de Fisiología y Farmacología, Universidad de Cantabria

 

 

Keywords: (−)Cannabidiol (PubChem CID: 12302390); 5-HT(1A) receptor; AM251 (PubChem CID: 2125); Antidepressant; Cannabidiol; Glutamate; Olfactory bulbectomy; Serotonin; WAY-100635 maleate salt (PubChem CID: 11957721)

 References

Linge R, Jiménez-Sánchez L, Campa L, et al. Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors. Neuropharmacology. 2016;103:16–26. doi:10.1016/j.neuropharm.2015.12.017

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