cbd dosage guide based on medical study results

CBD Dosage Medical Studies

These study summaries provide fact-based answers about CBD dosage and absorption.

  • how CBD absorption can be easily boosted 380%
  • safe CBD dosage tested across several studies
  • how long CBD remains in the blood
  • possible adverse effects

All the answers to your CBD questions are here so let’s get started.

If you don’t find an answer in this guide to a question you have, leave us a comment below and we’ll search the published studies to see if an answer exists and get back to you.

Increase CBD Absorption 380%

Learn the exact CBD absorption effects when taking CBD:

  • with a high-fat meal
  • with a low-fat meal
  • with milk
  • with alcohol

 

nih medical study

Published February 3, 2020

Study Results

CBD taken with a high-fat meal

520% increase in peak CBD blood concentration – 380% more effective than when taken orally without food. (1)                                                     nih CBD study

 

CBD taken with a low-fat meal 

270% increase in peak CBD blood concentration – 380% total increased exposure to CBD taken orally  (2)

nih cbd study

CBD taken with whole milk

240% increase in peak CBD blood concentration – 310% total increased exposure to CBD taken orally (3)                                                                        nih medical study                  

CBD taken with alcohol

160% increase in peak CBD blood concentration – 190% total increased exposure to CBD taken orally  (4)                                                                       nih medical study

Our Summary

CBD absorption rates were tested for a pure oral CBD product containing 750mg of CBD.

cannabidiol dose study

Procedure

  • 15 healthy adults consumed 750mg pure CBD with a high calorie/high-fat meal
  • 14 healthy adults consumed 750mg pure CBD with a low calorie/low-fat meal
  • 15 healthy adults consumed 750mg pure CBD with whole milk
  • 14 healthy adults consumed 750mg pure CBD with alcohol
  • 14 healthy adults consumed 750mg pure CBD after fasting/empty stomach
  • Blood samples were collected over a 96 hour period after ingesting the CBD product orally
  • Blood samples were evaluated by liquid chromatography and tandem mass spectrometry (5)

cbd dosage chart

Outcomes

CBD taken with food substantially increased the maximum amount of CBD in the blood as well as the total overall exposure of the body to CBD within 96 hours of taking an oral cannabidiol product.

Adverse effects

Cannabidiol side effects were minimal with no severe adverse effects. (6)

nih medical study

 

Further reading:  2020 medical study shows significant cardiovascular benefits from oral CBD.  See the study here.

Study Authors

Download the Study

CBD Dosage and Side Effects

CBD is generally well tolerated with mild side effects:

  • know exact side effects possible taking CBD
  • know how long it takes for CBD to reach peak concentration in the blood

nih medical study

Published November 3, 2018

Study Findings

  • CBD is generally well tolerated.
  • no serious or severe adverse effects from taking oral CBD in this study
  • CBD side effects were few and mild. (1)

nih medical study

Possible Adverse effects

  • diarrhea
  • nausea
  • headache
  • drowsiness (2)

nih medical study

Study Results

  • Taking oral CBD twice daily may be recommended given its minimal adverse effects and its diminishing concentration in the blood after a 10-17 hour period.
  • Peak CBD concentration in the blood occurred 4-5 hours after taking CBD dose.
  • The effective half-life of CBD in the blood was 10-17 hours.
  • Taking CBD orally with a high-fat meal significantly increased maximum blood concentrations. (3)

cannabidiol dosage guide

Our Summary

This was a phase 1, randomized, double-blind, placebo-controlled study.

By The Numbers

There were three groups of participants and multiple dosages:

  • single increasing dose group: CBD dosage of 1500mg, 3000mg, 4500mg or 6000mg (6 participants and 2 placebo participants per dosage group)
  • multiple-dose group (taking CBD dose twice daily): CBD dosage 750mg or 1500mg (9 participants and 3 placebo participants per dosage group)
  • oral CBD dose taken with high-fat meal group: CBD dosage 1500mg (12 participants and 0 placebo participants in this dosage group)
  • All participants completed the study. (4)

CBD side effects

Adverse Effects

  • there were no serious adverse effects recorded.
  • CBD group had increased instances of diarrhea and headaches compared to the placebo group.
  • all adverse effects were mild to moderate.
  • there were no “severe or serious” adverse effects. (5)

cbd dosage guide

 

 

Video: CBD oil side effects

 

 

Study Authors

Download The CBD Research

 

Keywords: cannabidiol dosage; adverse effects

Turbo CBD vs. Generic CBD

 

nih medical study

Published November 2019

Study Results

90mg TurboCBD vs. Generic CBD capsule

  • TurboCBD had 86% more CBD circulating in the body at 90 minutes
  • Turbo CBD had 65% more CBD circulating int the body at 120 minutes (1)

turbo cbd differences

Our Summary

This was a human trial to find out the absorption characteristics for a product called TurboCBD made by Lexaria Bioscience Corp. vs. generic CBD capsules. (2)

cannabidiol patient dosage

Evaluation

  • cannabidiol absorption
  • distribution
  • metabolism
  • excretion characteristics   

The study was funded by Lexaria Bioscience Corp. (3)

cannabidiol nih study

By The Numbers

  • 12 participants
  • double-blinded
  • placebo-controlled
  • cross-over design medical study. 

Each participant received 45mg or 90mg of generic CBD or TurboCBD capsules on five separate occasions.

45mg CBD capsule

TurboCBD capsules vs 45mg generic CBD capsules

  • no difference in circulating CBD at 90 minutes after ingestion
  • no difference in circulating CBD at 120 minutes after ingestion (4)

90mg CBD capsule

90mg TurboCBD capsules vs. a generic 90mg CBD capsule

  • 86% more CBD circulating at 90 minutes after ingestion
  • 65% more CBD circulating 120 minutes after ingestion (5)

After 4 hours

The TurboCBD product also caused an elevated CBD load in the bloodstream 4 hours after taking the capsules vs. a 90mg generic CBD capsule.

Conclusion

The higher cannabidiol bio-availability of the TurboCBD product causes greater absorption of CBD into the bloodstream and higher peak CBD loads. (6)

cannabidiol nih research

Study Authors

Download The CBD Research

Keywords: Cannabidiol; Cerebrovascular conductance; Gas chromatography-mass spectrometry; CBD Pharmacokinetics

CBD Dosage Study For Children

nih cannabidiol study

Published July 3, 2019

Study Results

7 children with childhood epilepsy had minimal to no adverse effects while taking an oral CBD for epilepsy product at dosages up to 10-12 mg CBD/kg/day. (1)

cannabidiol dosage study

By The Numbers

  • starting dose tested was 5-6 mg CBD/kg/day.
  • 1:20 THC to CBD ratio.

Benefit

The children had improvements in seizure frequency and quality of life scores. (2)

cbd nih dosage study

Intoxication

Levels of THC remained lower than what would be expected to cause intoxication. (3)

cannabidiol children dosage

Entourage Effect

The study said the best results occurred when a whole hemp plant product is used. (4)

cannabidiol dosage

Our Summary

This is preliminary data from the “Cannabidiol in Children with Refractory Epileptic Encephalopathy (CARE-E)” study.  

It is known that CBD helps with childhood epilepsy but cannabinoid dosage needs further investigation for adverse effects and long term use. (5)

cannabidiol dosage nih

The study started the children on a Cannabis plant extract at a dosage of 5-6 mg CBD/kg/day.

The dose was eventually increased to 10-12 mg CBD/kg/day.

The CBD product has a THC:CBD ratio of 1:20. (6)

cbd nih dosage study

Analysis

Data were collected for:

  • Seizure frequency
  • regular electroencephalograms
  • Quality of Life in Childhood Epilepsy (QOLCE)
  • Side Effects

Unexpected

The study suggests that concentrations of CBD in the blood may increase or decrease unexpectedly and further study is needed. (7)

Intoxication

The study also found that in doses of up to 10-12 mg CBD/kg/day at a THC:CBD ratio of 1:20 the level of THC in the blood remained low enough so that none of the children became intoxicated. (8)

cannabidiol dosage nih study

 

 

Study Authors

Download The CBD Research

 

Keywords: cannabidiol; cannabinoid plasma levels; cannabis; epileptic encephalopathy; Δ9-tetrahydrocannabinol

References

Crockett J, Critchley D, Tayo B, Berwaerts J, Morrison G. A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositions, whole milk, and alcohol on cannabidiol exposure and safety in healthy subjects. Epilepsia. 2020;61(2):267–277. doi:10.1111/epi.16419

Study Authors

GW Research Ltd, Cambridge, UK

GW Research Ltd, Cambridge, UK

 

GW Research Ltd, Cambridge, UK

 

GW Research Ltd, Cambridge, UK

 

GW Research Ltd, Cambridge, UK

 

 

References

Taylor L, Gidal B, Blakey G, Tayo B, Morrison G. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects [published correction appears in CNS Drugs. 2019 Apr;33(4):397]. CNS Drugs. 2018;32(11):1053–1067. doi:10.1007/s40263-018-0578-5

Study Authors

 

Taylor L

GW Research Ltd, Cambridge, UK

 Gidal B

University of Wisconsin School of Pharmacy

Blakey G

Consult2deliver Ltd, Nottingham, UK

Tayo B

GW Research Ltd, Cambridge, UK

Morrison G

[email protected]

GW Research Ltd, Cambridge, UK

 

 

References

Huntsman RJ, Tang-Wai R, Alcorn J, et al. Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study. Front Neurol. 2019;10:716. Published 2019 Jul 3. doi:10.3389/fneur.2019.00716

Study Authors

 

Huntsman RJ

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Department of Pediatrics, Royal University Hospital, University of Saskatchewan

 

Tang-Wai R

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Division of Child Neurology, Department of Pediatrics, Loma Linda University

 

Alcorn J

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

College of Pharmacy and Nutrition, University of Saskatchewan

 

Vuong S

College of Pharmacy and Nutrition, University of Saskatchewan

 

Acton B

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Saskatchewan Health Authority and Department of Psychology, University of Saskatchewan, Royal University Hospital

 

Corley S

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Clinical Trial Support Unit, Royal University Hospital, University of Saskatchewan

 

Laprairie R

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

College of Pharmacy and Nutrition, University of Saskatchewan

 

Lyon AW

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Department of Pathology and Laboratory Medicine, Royal University Hospital, Saskatchewan Health Authority

 

Meier S

Clinical Trial Support Unit, Royal University Hospital, University of Saskatchewan

 

Mousseau DD

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Cell Signalling Laboratory, Departments of Psychiatry and Physiology, University of Saskatchewan

 

Newmeyer D

Department of Pediatrics, Royal University Hospital, University of Saskatchewan

 

Prosser-Loose E

Department of Pediatrics, Royal University Hospital, University of Saskatchewan

 

Seifert B

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Department of Pharmaceutical Services, Royal University Hospital, Saskatchewan Health Authority

 

Tellez-Zenteno J

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Division of Neurology, Department of Medicine, Royal University Hospital, University of Saskatchewan

 

Huh L

Division of Pediatric Neurology, Department of Pediatrics, BC Children’s Hospital, University of British Columbia

 

Leung E

Division of Pediatric Neurology, Department of Pediatrics, Children’s Hospital, University of Manitoba

 

Major P

Service de Neurologie Pédiatrique, Département de Neurosciences, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal

 

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