CBD Dosage

This is a scientific guide.

Based on the latest medical studies.

  • know exactly how your body absorbs different types of CBD
  • know the optimal CBD dosages being tested and possible adverse effects

Let’s get started.

 

CBD Dosage Video

In this quick video, Dr. Liptan shows you how to find the right cannabidiol dosage for you.

 

 

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2020 CBD Research

Increase your peak CBD concentration by 520%

 

nih medical study

New CBD Research Published February 3, 2020

cbd research results

CBD Dosage Study Results:  

  • CBD taken with a high-fat meal – 520% increase in peak CBD blood concentration – 380% total increased exposure to CBD taken orally (1)  nih CBD study
  • CBD taken with a low-fat meal – 270% increase in peak CBD blood concentration – 380% total increased exposure to CBD taken orally  (2)nih cbd study
  • CBD taken with whole milk – 240% increase in peak CBD blood concentration – 310% total increased exposure to CBD taken orally (3)nih medical study
  • CBD taken with alcohol – 160% increase in peak CBD blood concentration – 190% total increased exposure to CBD taken orally  (4)nih medical study

cannabidiol study results graph

Our Summary: CBD absorption rates were tested for a pure oral CBD product containing 750mg of CBD.

cannabidiol dose study

Procedure: 

  • 15 healthy adults consumed 750mg pure CBD with a high calorie/high-fat meal
  • 14 healthy adults consumed 750mg pure CBD with a low calorie/low-fat meal
  • 15 healthy adults consumed 750mg pure CBD with whole milk
  • 14 healthy adults consumed 750mg pure CBD with alcohol
  • 14 healthy adults consumed 750mg pure CBD after fasting/empty stomach
  • Blood samples were collected over a 96 hour period after ingesting the CBD product orally
  •  blood samples were evaluated by liquid chromatography and tandem mass spectrometry (5)

cbd dosage chart

Outcomes: CBD taken with food substantially increased the maximum amount of CBD in the blood as well as the total overall exposure of the body to CBD within 96 hours of taking an oral cannabidiol product.

Adverse effects: Cannabidiol side effects were minimal with no severe adverse effects. (6)

nih medical study

Next Study: Compare Turbo CBD with Generic CBD

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Check out this quick video about finding the right CBD dosage for you.

Download the Study

Study Authors: 

GW Research Ltd, Cambridge, UK

GW Research Ltd, Cambridge, UK

 

GW Research Ltd, Cambridge, UK

 

GW Research Ltd, Cambridge, UK

 

GW Research Ltd, Cambridge, UK

References

Crockett J, Critchley D, Tayo B, Berwaerts J, Morrison G. A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositions, whole milk, and alcohol on cannabidiol exposure and safety in healthy subjects. Epilepsia. 2020;61(2):267–277. doi:10.1111/epi.16419

2018 CBD Research

nih medical study

 

CBD Study Published November 3, 2018

Study Results: 

  • CBD is generally well tolerated.
  • no serious or severe adverse effects from taking oral CBD in this study
  • CBD side effects were few and mild. (1)

nih medical study

Possible Adverse effects:

  • diarrhea
  • nausea
  • headache
  • drowsiness (2)

nih medical study

CBD Dosage Study Results:

  • Taking oral CBD twice daily may be recommended given its minimal adverse effects and its diminishing concentration in the blood after a 10-17 hour period.
  • Peak CBD concentration in the blood occurred 4-5 hours after taking CBD dose.
  • The effective half-life of CBD in the blood was 10-17 hours.
  • Taking CBD orally with a high-fat meal significantly increased maximum blood concentrations. (3)

cannabidiol dosage guide

Our Summary:   This was a phase 1, randomized, double-blind, placebo-controlled study.

By the numbers: There were three groups of participants and multiple dosages:

  • single increasing dose group: CBD dosage of 1500mg, 3000mg, 4500mg or 6000mg (6 participants and 2 placebo participants per dosage group)
  • multiple-dose group (taking CBD dose twice daily): CBD dosage 750mg or 1500mg (9 participants and 3 placebo participants per dosage group)
  • oral CBD dose taken with high-fat meal group: CBD dosage 1500mg (12 participants and 0 placebo participants in this dosage group)
  • All participants completed the study. (4)

CBD side effects

Adverse Effects:

  • there were no serious adverse effects recorded.
  • CBD group had increased instances of diarrhea and headaches compared to the placebo group.
  • all adverse effects were mild to moderate.
  • there were no “severe or serious” adverse effects. (5)

cbd dosage guide

 

Download The CBD Research

 

Next Study: Compare Turbo CBD with Generic CBD

 

Check out this video on CBD oil side effects.

 

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Study Authors:

Taylor L

GW Research Ltd, Cambridge, UK

 Gidal B

University of Wisconsin School of Pharmacy

Blakey G

Consult2deliver Ltd, Nottingham, UK

Tayo B

GW Research Ltd, Cambridge, UK

Morrison G

GMorrison@gwpharm.com

GW Research Ltd, Cambridge, UK

 

Keywords: cannabidiol dosage; adverse effects

References

Taylor L, Gidal B, Blakey G, Tayo B, Morrison G. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects [published correction appears in CNS Drugs. 2019 Apr;33(4):397]. CNS Drugs. 2018;32(11):1053–1067. doi:10.1007/s40263-018-0578-5

2019 CBD Research

nih medical study

CBD Study Published November 2019

Results: 90mg TurboCBD vs. Generic CBD capsule

  • TurboCBD had 86% more CBD circulating in the body at 90 minutes
  • Turbo CBD had 65% more CBD circulating int the body at 120 minutes (1)

turbo cbd differences

Our Summary:  This was a human trial to find out the absorption characteristics for a product called TurboCBD made by Lexaria Bioscience Corp. vs. generic CBD capsules. (2)

cannabidiol patient dosage

The study tested for:

  • cannabidiol absorption
  • distribution
  • metabolism
  • excretion characteristics   

The study was funded by Lexaria Bioscience Corp. (3)

cannabidiol nih study

By the numbers:

  • 12 participants
  • double-blinded
  • placebo-controlled
  • cross-over design medical study. 

Each participant received 45mg or 90mg of generic CBD or TurboCBD capsules on five separate occasions.

45mg CBD capsule:  TurboCBD capsules vs 45mg generic CBD capsules

  • no difference in circulating CBD at 90 minutes after ingestion
  • no difference in circulating CBD at 120 minutes after ingestion (4)

90mg CBD capsule:  90mg TurboCBD capsules vs. a generic 90mg CBD capsule

  • 86% more CBD circulating at 90 minutes after ingestion
  • 65% more CBD circulating 120 minutes after ingestion (5)

After 4 hours: The TurboCBD product also caused an elevated CBD load in the bloodstream 4 hours after taking the capsules vs. a 90mg generic CBD capsule.

Conclusion: The higher cannabidiol bio-availability of the TurboCBD product causes greater absorption of CBD into the bloodstream and higher peak CBD loads. (6)

cannabidiol nih research

Download The CBD Research

 

Next Study: CBD Dosage Research Children

 

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Study Authors:

Patrician A 

amdpatrician@gmail.com

Centre for Heart, Lung and Vascular Health, University of British Columbia

 

Versic-Bratincevic M

Department of Toxicology and Pharmacogenetics, University of Split School of Medicine

 

Mijacika T

Department of Integrative Physiology, University of Split School of Medicine

 

Banic I

Department of Integrative Physiology, University of Split School of Medicine

 

Marendic M

Department of Health Studies, University of Split

 

Sutlović D

Department of Toxicology and Pharmacogenetics, University of Split School of Medicine

Department of Pathology, Forensic Medicine and Citology, University Hospital Centre Split

 

Dujić Ž

Department of Integrative Physiology, University of Split School of Medicine

 

Ainslie PN

Centre for Heart, Lung and Vascular Health, University of British Columbia

 

 

Keywords: Cannabidiol; Cerebrovascular conductance; Gas chromatography-mass spectrometry; CBD Pharmacokinetics

References

Patrician A, Versic-Bratincevic M, Mijacika T, et al. Examination of a New Delivery Approach for Oral Cannabidiol in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Pharmacokinetics Study. Adv Ther. 2019;36(11):3196–3210. doi:10.1007/s12325-019-01074-6

2019 CBD Research

nih cannabidiol study

CBD Study Published July 3, 2019

Study Results:  7 children with childhood epilepsy had minimal to no adverse effects while taking an oral CBD for epilepsy product at dosages up to 10-12 mg CBD/kg/day. (1)

cannabidiol dosage study

By the numbers:

  • starting dose tested was 5-6 mg CBD/kg/day.
  • 1:20 THC to CBD ratio.

Benefit: The children had improvements in seizure frequency and quality of life scores. (2)

cbd nih dosage study

Intoxication: Levels of THC remained lower than what would be expected to cause intoxication. (3)

cannabidiol children dosage

Entourage Effect: The study said the best results occurred when a whole hemp plant product is used. (4)

cannabidiol dosage

Our Summary:   This is preliminary data from the “Cannabidiol in Children with Refractory Epileptic Encephalopathy (CARE-E)” study.  

It is known that CBD helps with childhood epilepsy but cannabinoid dosage needs further investigation for adverse effects and long term use. (5)

cannabidiol dosage nih

The study started the children on a Cannabis plant extract at a dosage of 5-6 mg CBD/kg/day.

The dose was eventually increased to 10-12 mg CBD/kg/day.

The CBD product has a THC:CBD ratio of 1:20. (6)

cbd nih dosage study

Analysis: Data were collected for:

  • Seizure frequency
  • regular electroencephalograms
  • Quality of Life in Childhood Epilepsy (QOLCE)
  • Side Effects

Unexpected: The study suggests that concentrations of CBD in the blood may increase or decrease unexpectedly and further study is needed. (7)

Intoxication: The study also found that in doses of up to 10-12 mg CBD/kg/day at a THC:CBD ratio of 1:20 the level of THC in the blood remained low enough so that none of the children became intoxicated. (8)

cannabidiol dosage nih study

Download The CBD Research

 

Check out this quick video on CBD benefits and dosages for children.

https://www.youtube.com/watch?v=gqdYQw4_m70

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Study Authors:

 

Huntsman RJ

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Department of Pediatrics, Royal University Hospital, University of Saskatchewan

 

Tang-Wai R

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Division of Child Neurology, Department of Pediatrics, Loma Linda University

 

Alcorn J

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

College of Pharmacy and Nutrition, University of Saskatchewan

 

Vuong S

College of Pharmacy and Nutrition, University of Saskatchewan

 

Acton B

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Saskatchewan Health Authority and Department of Psychology, University of Saskatchewan, Royal University Hospital

 

Corley S

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Clinical Trial Support Unit, Royal University Hospital, University of Saskatchewan

 

Laprairie R

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

College of Pharmacy and Nutrition, University of Saskatchewan

 

Lyon AW

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Department of Pathology and Laboratory Medicine, Royal University Hospital, Saskatchewan Health Authority

 

Meier S

Clinical Trial Support Unit, Royal University Hospital, University of Saskatchewan

 

Mousseau DD

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Cell Signalling Laboratory, Departments of Psychiatry and Physiology, University of Saskatchewan

 

Newmeyer D

Department of Pediatrics, Royal University Hospital, University of Saskatchewan

 

Prosser-Loose E

Department of Pediatrics, Royal University Hospital, University of Saskatchewan

 

Seifert B

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Department of Pharmaceutical Services, Royal University Hospital, Saskatchewan Health Authority

 

Tellez-Zenteno J

Cannabinoid Research Initiative of Saskatchewan, University of Saskatchewan

Division of Neurology, Department of Medicine, Royal University Hospital, University of Saskatchewan

 

Huh L

Division of Pediatric Neurology, Department of Pediatrics, BC Children’s Hospital, University of British Columbia

 

Leung E

Division of Pediatric Neurology, Department of Pediatrics, Children’s Hospital, University of Manitoba

 

Major P

Service de Neurologie Pédiatrique, Département de Neurosciences, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal

 

Keywords: cannabidiol; cannabinoid plasma levels; cannabis; epileptic encephalopathy; Δ9-tetrahydrocannabinol

References

Huntsman RJ, Tang-Wai R, Alcorn J, et al. Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study. Front Neurol. 2019;10:716. Published 2019 Jul 3. doi:10.3389/fneur.2019.00716

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