2020 Study: CBD Helps IBD, Improves Quality Of Life
Published January 4, 2020
- Individuals with inflammatory bowel disease have quality of life improvements after taking CBD. (1)
- CBD and CBG demonstrate beneficial effects in preclinical models of intestinal inflammation. (2)
- Cannabinoids made by the human body “have shown a regulatory role in inflammation and mucosal permeability of the gastrointestinal tract.”
- It is believed that endocannabinoids (those made by the human body) likely interact with the gut microbiome to regulate inflammation and mucosal permeability. (3)
CBD User Reports
Cannabis is reported by users to:
- block the sensation of pain in the gut
- have anti-inflammatory properties
- antidiarrheal properties (4)
While strong evidence of CBD’s beneficial effects on gastrointestinal diseases is still lacking, clinical trials of individuals with inflammatory bowel disease have shown improvement in quality of life even if they haven’t shown evidence of a reduction in inflammation. (5)
Video: CBD benefits for Inflammatory Bowel Disease
Keywords: Cannabis sativa; abdominal pain; diarrhea; inflammatory bowel disease; cannabidiol; endocannabinoid system;
Kienzl M, Storr M, Schicho R. Cannabinoids and Opioids in the Treatment of Inflammatory Bowel Diseases. Clin Transl Gastroenterol. 2020;11(1):e00120. doi:10.14309/ctg.0000000000000120
2019 Study: CBD For Crohn’s Disease
After taking CBD, patients had a substantial improvement in their Chrohn’s Disease symptoms. Patients’ average score on the Harvey-Bradshaw Index (a way of measuring Crohn’s disease symptoms) improved from 14 to 7. (1)
- The average dose of CBD consumed by patients to treat inflammatory bowel disease was 31 grams of cannabis per month.
- This CBD research found that most patients responded well to an inflammatory bowel disease treatment of 21mg/day THC and 170 mg/day CBD.
- The researchers conclude that “the majority of inflammatory bowel disease patients using cannabis are satisfied with a dose of 30 g/month.” (2)
This CBD research assessed the effects of using medical cannabis for treating inflammatory bowel disease. (3)
CBD dose and method of consumption, “adverse events, use of other medications, and long-term effects were evaluated among 127 patients with inflammatory bowel disease using legalized medical cannabis.” (4)
Patients were tested for:
- Blood count
- C-reactive protein
Patients were tested within one month of starting cannabidiol treatment for inflammatory bowel disease and at least one year after the therapy was started. (5)
Patients and one significant family member also completed questionnaires on:
- disease activity
- patient function
- signs of addiction (6)
- There was a small but statistically significant gain in weight of about 4 lbs. per patient.
- The use of other medications for inflammatory bowel disease decreased significantly after cannabis treatment was started.
- The employment of the patients increased from 65% to 74%. (7)
Researchers state they did not observe “negative effects of cannabis use on the patients’ social or occupational status.” (8)
Video: CBD benefits for Inflammatory Bowel Disaese.
Keywords: Cannabis sativa; inflammatory bowel disease; colon; abdominal pain; cannabidiol; endocannabinoid system; crohn’s disease
Naftali T, Bar-Lev Schleider L, Sklerovsky Benjaminov F, Lish I, Konikoff FM, Ringel Y. Medical cannabis for inflammatory bowel disease: real-life experience of mode of consumption and assessment of side-effects. Eur J Gastroenterol Hepatol. 2019;31(11):1376–1381. doi:10.1097/MEG.0000000000001565