CBD Effects on Chronic Pain and Insomnia

Medical cannabis improves:

  • chronic pain
  • insomnia (caused by chronic pain)
  • sleep duration (especially in older patients)
2020 Study: Patients taking CBD for pain had improved sleep quality. #cbd #pain #sleep tell a friend

 

 

nih medical study

Published January 20, 2020

 

 

Study Results

After factoring in variations for “age, sex, pain level, and use of [other] sleep and anti-depressant medications,” patients showed improvement in their sleep (1).

 

nih medical study

Who Benefits

Patients over the age of 50 with insomnia caused by chronic pain (2).

 

nih medical study

Benefit
  • Medical cannabis appeared to help patients stay asleep and kept them from waking up during the night (3).
  • Medical cannabis did not affect how quickly patients fell asleep nor the overall duration of their sleep (4).

nih medical study

Possible Adverse Effects

Frequent use of cannabis may not improve sleep (5).

 

nih medical study

Frequent Medical Cannabis Users Reported
  • increased difficulty falling asleep
  • increased difficulty staying asleep the whole night

 

 

 

 

Summary

More patients are preferring to take medical cannabis for their chronic pain and insomnia symptoms.

Participants

128 patients over the age of 50 were recruited from a local pain clinic.

66 were medical cannabis users and 62 did not use medical cannabis (6).

nih medical study

Analysis

Predictive modeling was used to assess the sleep differences in the two groups.

nih medical study

Statistical correlations were also made between sleep and the properties of the medical cannabis used such as:

  • dose
  • length of use
  • frequency of use
  • number of strains used
  • tetrahydrocannabinol levels
  • cannabidiol levels

nih medical study

 

 

 

 

Conclusion

The results of the study associated medical cannabis use with fewer Sleep Maintenance Insomnia symptoms but medical cannabis use did not affect Sleep Onset Insomnia nor overall sleep duration in older patients with chronic pain (7).

nih medical study

 

 

CBD inflammation benefits have a positive impact on neurodegenerative diseases like dementia and Alzheimer’s, according to a 2020 medical study.  See the study results here.

 

 

Video: How are patients using medical cannabis for chronic pain relief?

 

Study Authors

Download The CBD Research

 

 

 

Keywords: chronic pain; insomnia; medical cannabis; sleep

 

 

Back to table of contents ⤴

 

CBD Effects On Neuropathic Pain

  • Topical CBD cream significantly improves neuropathic pain.

 

2019 Study: Topical CBD skin cream relieves pain in patients with peripheral neuropathy. #cbd #pain #diabetes tell a friend

 

nih medical study

Published December 1, 2019

 

 

 

 

Study Results

There was a “significant reduction in intense pain, sharp pain, cold and itchy sensations in the CBD group when compared to the placebo group.” (1)

cannabidiol pain relief

Who Benefits

  • Patients with chronic pain and neuropathic pain not caused by cancer (2).
  • The average age of patients in the study was 68 years (3)

cannabidiol pain treatment

Benefit
  • The researchers concluded that transdermal application (topical CBD cream) can relieve pain in patients with peripheral neuropathy.
  • CBD cream may provide an alternative to other treatments for neuropathic pain (4).

cannabidiol pain study

Adverse Effects

There were no adverse events noted in this study.  Cannabidiol was well tolerated by all participants with minimal to no side effects in this study.

 

 

 

 

Summary

This new CBD research aims to examine the pain-relieving properties of topical CBD cream for the treatment of chronic and neuropathic pain not caused by cancer.

Method

  • 4 week
  • randomized
  • placebo-controlled
  • 29 patients with neuropathic pain symptoms  (divided into two groups)

cannabidiol pain relief

 

 

 

Topical CBD Cream Dosage

One group received a CBD topical cream dose of 250 mg CBD/3 fl. oz while the other received a placebo.

After 4 weeks the placebo group was allowed to transfer over to receive treatment with the CBD cream (5).

Patients

  • The participants in the study had an average age of 68 years.
  • Two-thirds were male and one-third female.

 

In a 2019 medical study, CBD was shown to reduce pain and inflammation from Rheumatoid Arthritis.  See a summary of the results here.

 

 

 

Video: CBD for neuropathic pain relief

 

Study Authors

 

 

Download The CBD Research

 

 

Keywords: CBD; Chronic Pain; Cannabis sativa; Diabetic neuropathy; Hemp; Nerve pain; Review

 

 

Back to table of contents ⤴

 

CBD Effects On Chronic Pain And Opioid Dependency

  • CBD significantly reduces opioid painkillers use in patients who struggle with chronic pain.

nih medical study

 Published November 12, 2019

 

 

 

 

 

Study Results

  • 53% of chronic pain patients reduced or eliminated their prescribed opioid use within 8 weeks of adding CBD to their pain treatment.
  • 94% of study participants reported quality of life improvements from taking CBD.
  •  strong relationship between CBD and improvements in chronic pain intensity as well as better sleep quality (1).

 

nih medical research

 

 

Who Benefits

  • Ages 30-65
  • taking opiates prescribed by a doctor for more than 1 year
  • patients with chronic pain (2)

 

Benefit
  • reduce or eliminate opiates from pain management treatment
  • better sleep
  • improved reported quality of life (3)

 

cbd pain relief

 

 

 

Conclusion

Cannabidiol could reduce opioid use and improve the quality of sleep for patients who take pharmaceutical opiates for chronic pain (4).

 

 

 

Summary

  • 131 patients were recruited from a pain management clinic.
  • Of the 131 patients, 97 completed the 8 week CBD research study.
  • Patients were ages 30-65.
  • Before the study, patients were using opioids for at least one year to treat chronic pain symptoms (5).

 

nih medical study

 

 

 

Evaluation

Improvements in chronic pain symptoms were evaluated using 4 tests:

  • Pain Disability Index (PDI-4) (positive trend results, but not significant)
  • Pittsburgh Sleep Quality Index (PSQI) (a significant improvement from CBD use)
  • Pain Intensity and Interference (PEG) (a significant improvement from CBD use)
  • Patient Health Questionnaire (PHQ-4) (positive trend results, but not significant) (6)

 

cannabidiol pain research

CBD significantly reduces withdrawal symptoms from opioids including cravings and anxiety, according to 2019 medical study.  See the full study results here.

 

 

 

Video: CBD for Opiod Dependence.

 

Study Authors

Download The CBD Research

 

Keywords: Cannabinoid; cannabidiol; cannabis; chronic pain; opioids; sleep

 

 

Back to table of contents ⤴

 

 

CBD Effects on Pain and Inflammation

  • There are several CBD delivery methods for helping pain and inflammation relief.

 

2018 Study: CBD has wide-ranging benefits for relieving pain and inflammation. #cbd #pain tell a friend

 

 

nih medical study

Published August 2018

Summary

This CBD study focuses on different delivery methods of cannabidiol for pain and inflammation.

 

cannabidiol bowel pain

Benefits

CBD has possible benefits for treating a wide variety of conditions including :

  • pain
  • inflammation
  • epilepsy
  • sleep disorders
  • symptoms of multiple sclerosis
  • anorexia
  • schizophrenia (1)
  • and more

 

nih medical study

Types of CBD

This study is a review of different methods for delivering CBD for treating pain and inflammation including oral, transdermal, and nanotechnology-based drug delivery strategies (2).

 

cbd pain treatments

 

 

CBD has significant benefits for neurological disorders, according to a 2019 medical study.  See the full results here.

Study Authors

 

Download The CBD Research

 

 

Keywords: cannabidiol; cannabinoids; delivery system; inflammation; pain treatment; Δ9-tetrahydrocannabinol

 

 

Back to table of contents ⤴

 

 

CBD Effects On Chronic Pain

  • Historical perspective on cannabinoid use in pain management

 

2018 Study: Cannabinoids have been used to treat pain for thousands of years. #cbd #pain tell a friend

 

nih medical study

 Published November 2018

 

 

 

History

  • Cannabinoids have been used for treating medical conditions for thousands of years.
  • Cannabis as medicine stopped during the mid-twentieth century due to the prohibition against marijuana.

nih medical study

  • Cannabis is most commonly used to treat chronic pain (1).                                                                                                                                                       nih medical study

 

Our Summary

Cannabis and CBD hold substantial promise for treating:

  • pain
  • chronic pain
  • neuropathic pain

nih medical study

 

 

 

 

Adverse Effects

  • Cannabidiol side effects are minimal to moderate according to the study and generally stop if treatment is ended (2).

 

nih medical study

 

  • Long-term use of cannabidiol has not been studied well enough to have a clear understanding of the possible adverse effects.

nih medical study

 

Conclusion

  • There is a lack of information as to the long term effects of using cannabis and cannabinoids for treating pain.
  • More research needs to be conducted to confirm its cannabidiol’s long term safety record (3).

 

nih medical study

 

Already tried CBD? Interested in trying something new? CBG (cannabigerol) significantly reduces pain and inflammation, according to a 2020 medical study.  Full guide to CBG benefits here.

 

 

 

Study Authors

 

Download The CBD Research

 

Keywords: animals; cannabis/cannabinoids; efficacy; humans; pain; pharmacodynamics; pharmacokinetics; safety

 

CBD Effects On Arthritis Pain

  • Topical CBD cream benefits arthritis

 

2016 Study: CBD may have benefits for treating pain in patients with arthritis. #cbd tell a friend

 

nih medical study

 Published July 2016

 

 

 

 

Study Results

  • CBD has benefits for treating pain particularly in patients who struggle with arthritis (1).
  • CBD does not have good absorption rates when taken orally (2).

nih medical study

 

Summary

This study aims to research absorption rates and pain relief of cannabidiol when applied as a topical skin cream.

nih medical study

 

Conclusion

The study finds that CBD skin cream does treat pain and inflammation from arthritis (3).

nih medical study

 

 

Have you ever tried terpenes? Though many terpenes have pain-relieving effects, not all terpenes from hemp relieve pain.  Some, like guiaol, even have “anti-analgesic” effects, according to a 2018 medical study.  See the full results in this comprehensive guide to CBD Terpene Benefits.

 

 

Study Authors

 

Download The CBD Research

 

 

 

Keywords: cannabidiol, pain, inflammation

 

References

Sznitman SR, Vulfsons S, Meiri D, Weinstein G. Medical cannabis and insomnia in older adults with chronic pain: a cross-sectional study [published online ahead of print, 2020 Jan 20]. BMJ Support Palliat Care. 2020;bmjspcare-2019-001938. doi:10.1136/bmjspcare-2019-001938

References

Xu DH, Cullen BD, Tang M, Fang Y. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities [published online ahead of print, 2019 Dec 1]. Curr Pharm Biotechnol. 2019;10.2174/1389201020666191202111534. doi:10.2174/1389201020666191202111534

References

Capano A, Weaver R, Burkman E. Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgrad Med. 2020;132(1):56–61. doi:10.1080/00325481.2019.1685298

References

Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018;23(10):2478. Published 2018 Sep 27. doi:10.3390/molecules23102478

References

Vučković S, Srebro D, Vujović KS, Vučetić Č, Prostran M. Cannabinoids and Pain: New Insights From Old Molecules. Front Pharmacol. 2018;9:1259. Published 2018 Nov 13. doi:10.3389/fphar.2018.01259

References

Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviors in a rat model of arthritis. Eur J Pain. 2016;20(6):936–948. doi:10.1002/ejp.818

Pin It on Pinterest

Share This