CBD For Pain

This is a scientific guide.

Based on the latest medical studies.

Know the exact CBD benefits for:

  • hard to treat pain
  • chronic pain
  • neuropathic pain

Let’s get started.

 

CBD Benefits: Chronic Pain

Medical cannabis patients improve insomnia caused by chronic pain.

Does Medical Cannabis help insomnia caused by chronic pain?

 

nih medical study

Pain Relief Research Published On January 20, 2020

cbd research results

 

Study Results: After factoring in variations for “age, sex, pain level, and use of [other] sleep and anti-depressant medications,” patients showed improvement in their sleep (1).

nih medical study

Who Benefits: Patients over the age of 50 with insomnia caused by chronic pain (2).

nih medical study

Benefit:

  • Medical cannabis appeared to help patients stay asleep and kept them from waking up during the night (3).
  • Medical cannabis did not affect how quickly patients fell asleep nor the overall duration of their sleep (4).

nih medical study

Possible adverse effects:  Frequent use of cannabis may not improve sleep (5).

nih medical study

Frequent medical cannabis users reported:

  • increased difficulty falling asleep
  • increased difficulty staying asleep the whole night

cannabidiol study results graph

 

Our Summary:  More patients are preferring to take medical cannabis for their chronic pain and insomnia symptoms.

In this study: 128 patients over the age of 50 were recruited from a local pain clinic.

66 were medical cannabis users and 62 did not use medical cannabis (6).

nih medical study

Analysis: Predictive modeling was used to assess the sleep differences in the two groups.

nih medical study

Statistical correlations were also made between sleep and the properties of the medical cannabis used such as:

  • dose
  • length of use
  • frequency of use
  • number of strains used
  • tetrahydrocannabinol levels
  • cannabidiol levels

nih medical study

Conclusion: The results of the study associated medical cannabis use with fewer Sleep Maintenance Insomnia symptoms but medical cannabis use did not affect Sleep Onset Insomnia nor overall sleep duration in older patients with chronic pain (7).

nih medical study

 

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Check out this quick video to learn how people are using medical cannabis for chronic pain relief.

 

Study Authors:

Sznitman SR

School of Public Health, University of Haifa Faculty of Social Welfare and Health Sciences

 

Vulfsons S 

Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology

Institute of Pain Medicine, Rambam Health Care Campus

Meiri D

Department of Biology, Technion Israel Institute of Technology

Weinstein G

School of Public Health, University of Haifa Faculty of Social Welfare and Health Sciences

Keywords: chronic pain; insomnia; medical cannabis; sleep

References

Sznitman SR, Vulfsons S, Meiri D, Weinstein G. Medical cannabis and insomnia in older adults with chronic pain: a cross-sectional study [published online ahead of print, 2020 Jan 20]. BMJ Support Palliat Care. 2020;bmjspcare-2019-001938. doi:10.1136/bmjspcare-2019-001938

CBD Benefits: Neuropathic Pain

CBD cream significantly improves neuropathic pain.

CBD for neuropathic pain relief?

nih medical study

New CBD Research Published December 1, 2019

cbd study research results

 

Study Results:   There was a “significant reduction in intense pain, sharp pain, cold and itchy sensations in the CBD group when compared to the placebo group.” (1)

cannabidiol pain relief

Who Benefits:

  • Patients with chronic pain and neuropathic pain not caused by cancer (2).
  • The average age of patients in the study was 68 years (3)

cannabidiol pain treatment

Benefit:

  • The researchers concluded that transdermal application (topical CBD cream) can relieve pain in patients with peripheral neuropathy.  
  • CBD cream may provide an alternative to other treatments for neuropathic pain (4).

cannabidiol pain study

Adverse Effects: There were no adverse events noted in this study.  Cannabidiol was well tolerated by all participants with minimal to no side effects in this study.

 

cannabidiol research 2019

Our summary:  This new CBD research aims to examine the pain-relieving properties of topical CBD cream for the treatment of chronic and neuropathic pain not caused by cancer.

By the numbers:

  • 4 week
  • randomized
  • placebo-controlled
  • 29 patients with neuropathic pain symptoms  (divided into two groups)

cannabidiol pain relief

Topical CBD Cream Dosage: One group received a CBD topical cream dose of 250 mg CBD/3 fl. oz while the other received a placebo.  

After 4 weeks the placebo group was allowed to transfer over to receive treatment with the CBD cream (5).

Patients:

  • The participants in the study had an average age of 68 years. 
  • Two-thirds were male and one-third female.

 

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Check out this quick video about CBD for neuropathic pain relief.

Study Authors:

Xu DH

PGY-2, Department of Podiatric Medicine and Surgery, Scripps Mercy Hospital, San Diego, CA 92103, United States

Cullen BD

Podiatric Surgery Section Chief, Scripps Mercy Hospital, San Diego, 92103, United States.

Tang M

Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, 50312, United States

Fang Y

Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, 50312, United States

Keywords: CBD; Chronic Pain; Cannabis sativa; Diabetic neuropathy; Hemp; Nerve pain; Review

References 

Xu DH, Cullen BD, Tang M, Fang Y. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities [published online ahead of print, 2019 Dec 1]. Curr Pharm Biotechnol. 2019;10.2174/1389201020666191202111534. doi:10.2174/1389201020666191202111534

CBD Benefits: Chronic Pain

CBD significantly reduces dependence on opioid painkillers in chronic pain patients.

Can CBD help chronic pain patients stop taking opioid painkillers?

 

nih medical study

 

New CBD Research Published November 12, 2019

cbd study research results

 

Study Results:  

  • 53% of chronic pain patients reduced or eliminated their prescribed opioid use within 8 weeks of adding CBD to their pain treatment.
  • 94% of study participants reported quality of life improvements from taking CBD.
  •  strong relationship between CBD and improvements in chronic pain intensity as well as better sleep quality (1).

nih medical research

Who benefits:

  • Ages 30-65
  • taking opiates prescribed by a doctor for more than 1 year
  • patients with chronic pain (2)

Benefit: 

  • reduce or eliminate opiates from pain management treatment
  • better sleep
  • improved reported quality of life (3)

cbd pain relief

Conclusion: Cannabidiol could reduce opioid use and improve the quality of sleep for patients who take pharmaceutical opiates for chronic pain (4).

cannabidiol study results graph

Our summary:  131 patients were recruited from a pain management clinic.

Of the 131 patients, 97 completed the 8 week CBD research study.

Patients were ages 30-65.

Before the study, patients were using opioids for at least one year to treat chronic pain symptoms (5).

nih medical study

Evaluation: Improvements in chronic pain symptoms were evaluated using 4 tests:

  • Pain Disability Index (PDI-4) (positive trend results, but not significant)
  • Pittsburgh Sleep Quality Index (PSQI) (a significant improvement from CBD use)
  • Pain Intensity and Interference (PEG) (a significant improvement from CBD use)
  • Patient Health Questionnaire (PHQ-4) (positive trend results, but not significant) (6)

cannabidiol pain research

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Check out this helpful video on CBD for Opiod Dependence.

 

 

Study Authors:

Capano A

Ecofibre Ltd, Philadelphia, PA, USA

Lambert Center for the Study of Medicinal Cannabis & Hemp Philadelphia

 Weaver R

University of Louisville

 

Burkman E

University of Louisville

Keywords: Cannabinoid; cannabidiol; cannabis; chronic pain; opioids; sleep

References

Capano A, Weaver R, Burkman E. Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgrad Med. 2020;132(1):56–61. doi:10.1080/00325481.2019.1685298

CBD Benefits: Pain and Inflammation

Medical research into the best CBD delivery methods for pain and inflammation relief.

nih medical study

CBD Study Published August 2018

Our Summary:  This CBD study focuses on different delivery methods of cannabidiol for pain and inflammation.

cannabidiol bowel pain

Benefits: CBD has possible benefits for treating a wide variety of conditions including :

  • pain
  • inflammation
  • epilepsy
  • sleep disorders
  • symptoms of multiple sclerosis
  • anorexia
  • schizophrenia (1)
  • and more 

nih medical study

Types of CBD: This study is a review of different methods for delivering CBD for treating pain and inflammation including oral, transdermal and nanotechnology-based drug delivery strategies (2).

cbd pain treatments

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Study Authors:

Natascia Bruni

natascia.bruni@candioli.it

Istituto Farmaceutico Candioli, 10092 Beinasco, Italy

Carlo Della Pepa

carlo.dellapepa@unito.it

Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy

Simona Oliaro-Bosso

simona.oliaro@unito.it

Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy

Enrica Pessione

enrica.pessione@unito.it

Department of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy

Daniela Gastaldi

daniela.gastaldi@unito.it

Department of Molecular Biotechnology and Health Sciences, University of Turin, 10125 Turin, Italy 

Dosio F

franco.dosio@unito.it

Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy

 

Keywords: cannabidiol; cannabinoids; delivery system; inflammation; pain treatment; Δ9-tetrahydrocannabinol

References

Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018;23(10):2478. Published 2018 Sep 27. doi:10.3390/molecules23102478

CBD: Traditional Pain Relief

Historical perspective on cannabinoid use in traditional medicine pain management.

nih medical study

 

CBD Study Published November 2018

History:

  • Cannabinoids have been used for treating medical conditions for thousands of years.
  • Cannabis as medicine stopped during the mid-twentieth century due to the prohibition against marijuana.

nih medical study

  • Cannabis is most commonly used to treat chronic pain (1).                                                                                                                                                       nih medical study

 

Our Summary:  

Cannabis and CBD hold substantial promise for treating:

  • pain
  • chronic pain
  • neuropathic pain

nih medical study

Adverse Effects:

  • Cannabidiol side effects are minimal to moderate according to the study and generally stop if treatment is ended (2).

nih medical study

  • Long-term use of cannabidiol has not been studied well enough to have a clear understanding of the possible adverse effects.             nih medical study

Conclusion:

  • There is a lack of information as to the long term effects of using cannabis and cannabinoids for treating pain.
  • More research needs to be conducted to confirm its cannabidiol’s long term safety record (3).

nih medical study

 

 

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Study Authors:

Sonja Vučković

Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Dragana Srebro

Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Katarina Savić Vujović

Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Čedomir Vučetić

Clinic of Orthopaedic Surgery and Traumatology, Clinical Center of Serbia, Belgrade, Serbia

Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Milica Prostran

Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Keywords: animals; cannabis/cannabinoids; efficacy; humans; pain; pharmacodynamics; pharmacokinetics; safety

References

Vučković S, Srebro D, Vujović KS, Vučetić Č, Prostran M. Cannabinoids and Pain: New Insights From Old Molecules. Front Pharmacol. 2018;9:1259. Published 2018 Nov 13. doi:10.3389/fphar.2018.01259

CBD Benefits: Arthritis Pain

CBD cream benefits in animal models.  Early research.

References

Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2016;20(6):936–948. doi:10.1002/ejp.818

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