2019 CBD Research
CBD for Rheumatoid Arthritis pain and inflammation?
New research says: Yes
- CBD has anti-inflammatory properties which may be helpful in the treatment of Rheumatoid Arthritis
- THC has some pro-inflammatory properties which can be decreased by CBD
- CBD has some anti-arthritic properties beyond decreasing inflammation
How does CBD work: CBD decreases arthritic pain through its interaction with the endocannabinoid system (ECS).
New CBD Study Published May 23 2019
Our summary: Activation of the CB2 receptor (the CBD receptor) in the endocannabinoid system causes a “decrease cytokine production and immune cell mobilization” both of which play a role in Rheumatoid Arthritis.
On the other hand, activation of the CB1 receptor (the THC receptor) causes an inflammatory response.
CBD down-regulates the CB1 receptor when it is activated by THC. This downregulation of the CB1 receptor may provide an anti-inflammatory response “by increasing β2-adrenergic signaling in the joint and secondary lymphoid organs.”
Pain reducing: Cannabidiol has also been shown to have anti-arthritic properties beyond reducing inflammation.
- Cannabinoids, in general, have shown the ability to reduce pain by “activating central and peripheral CB1, peripheral CB2 receptors and CBD-sensitive noncannabinoid receptor targets.”
- Even though THC may cause inflammation, it may be the case that its pain-relieving properties still make it suitable to take in the context of relieving joint pain.
Interaction CBD/THC: CBD has been shown to “down modulate” how THC interacts with the CB1 receptor in the endocannabinoid system.
In the context of Rheumatoid Arthritis, CBD appears to have a number of beneficial properties.
It is likely the case that CBD taken together with THC would be the most helpful cannabinoid course for symptoms of RA.
Conclusion: “Cannabinoids might be a suitable treatment for RA, but it is important to target the right receptors in the right place.”
Check out this comprehensive video on taking cannabinoids for arthritis pain.