CBD Reduces Inflammation

This is a scientific guide.

Based on the latest medical studies.

  • know exactly how CBD affects Rheumatoid Arthritis
  • know the optimal CBD dosages tested and possible adverse effects
  • find out how CBD may benefit your arthritis pain

Let’s get started.


2019 CBD Research

CBD for Rheumatoid Arthritis pain and inflammation?

New research says: Yes

cannabidiol nih study

New CBD Study Published May 23, 2019

cbd research results


Latest findings: 

  • CBD has anti-inflammatory properties which may be helpful in the treatment of Rheumatoid Arthritis
  • THC has some pro-inflammatory properties which can be decreased by CBD
  • CBD has some anti-arthritic properties beyond decreasing inflammation (1)

How does CBD work: CBD decreases arthritic pain through its interaction with the endocannabinoid system (ECS).


cannabidiol study results graph


Our summary:  Activation of the CB2 receptor (the CBD receptor) in the endocannabinoid system causes a “decrease cytokine production and immune cell mobilization” both of which play a role in Rheumatoid Arthritis.

On the other hand, activation of the CB1 receptor (the THC receptor) causes an inflammatory response. 

CBD down-regulates the CB1 receptor when it is activated by THC.  This downregulation of the CB1 receptor may provide an anti-inflammatory response “by increasing β2-adrenergic signaling in the joint and secondary lymphoid organs.” (2)

rheumatoid arthritis study

Pain reducing: Cannabidiol has also been shown to have anti-arthritic properties beyond reducing inflammation.

  • Cannabinoids, in general, have shown the ability to reduce pain by “activating central and peripheral CB1, peripheral CB2 receptors and CBD-sensitive noncannabinoid receptor targets.” (3)
  • Even though THC may cause inflammation, it may be the case that its pain-relieving properties still make it suitable to take in the context of relieving joint pain. (4)

Interaction CBD/THC: CBD has been shown to “down modulate” how THC interacts with the CB1 receptor in the endocannabinoid system.

In the context of Rheumatoid Arthritis, CBD appears to have a number of beneficial properties.

It is likely the case that CBD taken together with THC would be the most helpful cannabinoid course for symptoms of RA.

Conclusion: “Cannabinoids might be a suitable treatment for RA, but it is important to target the right receptors in the right place.” (5)

CBD rheumatoid arthritis


Download The CBD Research


Check out this comprehensive video on the science behind taking CBD for arthritis.


Study Authors:

Lowin T

Poliklinik, Funktionsbereich & Hiller Forschungszentrum für Rheumatologie, University Hospital Duesseldorf

Schneider M

Poliklinik, Funktionsbereich & Hiller Forschungszentrum für Rheumatologie, University Hospital Duesseldorf

Pongratz G

Poliklinik, Funktionsbereich & Hiller Forschungszentrum für Rheumatologie, University Hospital Duesseldorf


Keywords: CBD; Cannabis; Rheumatoid Arthritis; Inflammation; Joint Pain


Lowin T, Schneider M, Pongratz G. Joints for joints: cannabinoids in the treatment of rheumatoid arthritis. Curr Opin Rheumatol. 2019;31(3):271–278. doi:10.1097/BOR.0000000000000590

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