Table of Contents

What are terpenes?

This is a scientific guide backed by the latest studies.

  • learn the smell and taste of the best cannabis terpenes
  • match terpenes to their exact effects
  • learn how to boost the terpene entourage effect
  • learn how to identify strains with beneficial terpene profiles

Let’s get started.

What are terpenes?

Cannabis strains make organic compounds called terpenes along with cannabinoids like CBD.

Terpene definition: terpenes are aromatic compounds found in cannabis strains.  They are what give each variety its unique smell and flavor.

As well as their distinctive smell and flavor, terpenes have a wide range of health benefits.

hemp terpene properties

Terpenes are created in the flowers (buds) of cannabis plants.

Some of the same terpenes found in CBD cannabis strains are also found in fruits and vegetables.

Terpenes Are Everywhere

There are over 120 known terpenes in cannabis.

The best CBD terpenes have significant health benefits and mood-altering properties.

Terpenes are the aromatic compounds that give cannabis strains like Suver Haze and Charlotte’s Cherries their well-known taste and smell.

terpene health benefits

 

Terpene Benefits

Terpenes relieve stress, anxiety, depression, and insomnia. (1)

cannabidiol terpene study

Terpenes can:

  • uplift mood
  • relax mind and muscles
  • anti-inflammation properties
  • anti-anxiety
  • fight stress
  • analgesic properties (pain relief)

Entourage Effect

Terpenes and terpene oil can be mixed with CBD.

This will increase the effects of both the terpenes and CBD. (2)

Terpenes mixed with CBD amplify and target the health benefits of each compound.

That is referred to as the entourage effect.

cannabidiol boost benefit

If you take the right terpene isolates and CBD oil together, you can boost the overall effects you experience.

Example? Try adding the terpene linalool to your CBD oil.  It will increase the relaxing effect of your CBD.

Are you interested in deepening the anti-anxiety sedative effects of CBN (cannabinol)?

Read the guide below to find out how:

anti-anxiety terpene sedative

If you’re interested in a super relaxing CBD effect, find a CBD cannabis strain high in the terpene terpineol.

The terpineol is thought to cause the “couch-lock effect.”

The couch-lock effect is usually associated with Indica cannabis strains. (3)

CBD and terpenes working together is called “entourage effect” or cannabis synergy. (4)

terpene cannabidiol synergy

The terpene terpineol is thought to cause the couch-lock effect associated with Indica strains. tell a friend

Terpene Profile

The terpene profile is what gives a particular strain its characteristic smell and taste.

Variations in the terpene profile also account for the unique effects of individual cannabis strains.

Learn which CBD cannabis strains will keep your head clear and help productivity.  Click on the guide below.

anti-anxiety terpene profile

After learning about individual terpenes, you will be able to identify subtle aroma and taste variations in cannabis.

And better yet, you’ll know what effects to expect after consuming.

You’ll even be able to tell friends the scientific reasons why one strain affects them differently than another.

And you’ll be a more knowledgable buyer the next time you go to a dispensary.

Example? Many CBD cannabis strains have a strong citrus smell.

A strong citrus scent usually means a cannabis strain is high in the terpene limonene.

limonene terpene cbd hemp

Limonene is known for its uplifting effects on mood.

Plan on using cannabis strains high in limonene for an active Saturday.

Cannabis strains high in limonene are usually very social and energizing strains.

Knowing about terpenes will help guide you and friends in buying decisions — the more you know, the more likely you are to get the effect you expect.

Besides, it’s always cool when you know more than the budtender.

Making Sense of 120 Terpenes

Terpene charts show up to 120 different terpenes found in high CBD cannabis strains. (5)

That’s too many.

Most of those terpenes are present in very small quantities anyway.

The 16 terpenes in the list below are the ones that will have the most effect on your experience.

Scroll down to learn the exact smell, taste, and effects of the 16 best CBD terpenes.

A strong citrus scent usually means a hemp strain is high in the terpene limonene. tell a friend

 

limonene terpene graphic displaying limonene molecular structure

Limonene Terpene

 

Limonene is a common terpene in CBD cannabis strains.

Limonene is found in cannabis and citrus fruits like lemons and oranges.

limonene smells similar to citrus and lemons

According to multiple studies, a CBD cannabis strain with a lemon-like scent might be all that’s needed to uplift your mood.

terpene benefits uplifting effects

The terpene limonene has been shown scientifically to provide a quick pick-me-up and a subtle mood lift. (6)

Cannabis strains high in limonene are easily identified by their lemon-like smell and taste.

Scientific studies actually show that cannabis strains with pleasant-smelling terpene profiles (like limonene) may even make you feel happier during stressful situations. (7)

terpene effects guide

You might want to try mixing limonene with different cannabinoids (other than CBD).

Try limonene with CBN (cannabinol).

The combination of the two has a dual effect.  It is both relaxing for the body and uplifting for mind and mood.

The extra benefits derived from mixing limonene with CBN is a good example of the terpene entourage effect.

More about that entourage effect below.

Limonene Entourage Effect

 

Entourage effect definition: terpenes and cannabinoids (like CBD or CBN) work together to amplify and target the benefits of each compound. (8)

cannabidiol terpene synergy

Learning how to dose CBD oil with complimentary terpenes is one of the reasons you’re reading this guide.

The terpene entourage effect will help you to get the full advantage of both compounds.

Once you successfully dial in the entourage effect for your body, CBD products become more effective.

The Entourage effect (cannabinoid synergy) effectively increases the strength of your CBD products. (9)

terpene entourage effect example

As you can see from the terpene list below for the Kashmir Blue strain, breeders of medical cannabis selectively breed for cannabinoid and terpene content.

limonene hemp terpene

For example, medical studies show hemp strains with substantial amounts of limonene fight stress, anxiety, depression and boost confidence. (10)

terpene chemovar strain breeding

The terpene entourage effect increases the strength of your CBD products and extends the duration of their benefits. tell a friend

Limonene Health Benefits

 

Studies show limonene may have cancer-preventive properties for breast cancer and colorectal cancers. (11)

terpene health benefits

Additionally, Limonene has strong anti-inflammatory properties.

Limonene anti-inflammatory and cholesterol dissolving properties may be helpful to cardiovascular health as well as gut disorders like Colitis and Crohn’s disease. (12)

terpene heart benefit

Multiple studies show Limonene aids in treating heartburn and gastroesophageal reflux disorder (GERD). (13)

limonene heartburn effects

Though unproven, it is thought limonene has beneficial properties for weight control and skincare.

These claims require further study.

Interested in using CBD in your skincare routine? This 2020 medical study shows CBD has skincare benefits for inflammatory skin conditions.

terpene health benefits

Studies show the terpene limonene may have cancer-preventive properties for breast cancer and colorectal cancers. tell a friend

 

Limonene Adverse Effects

Limonene is present in many citrus fruits.

It is considered to have low human toxicity and minimal to no adverse effects in normal consumption patterns. (14)

limonene terpene toxicity

 

 

Myrcene Terpene

 

Is anxiety a part of your life? Try CBD with myrcene.  It really helps.

Myrcene Smell and Taste

Myrcene is found numerous CBD cannabis strains.

It’s also found in large volumes in fruits like mango, and especially wild thyme.

the terpene myrcene is found in large quantities in mangoes

Myrcene makes up a substantial percentage of the essential oil that can be distilled from cannabis.

If you’re CBD flower has a “fruity” aroma, there’s a good chance you’re smelling myrcene.

The terpene myrcene has a fruit-like scent and is found in high quantities in mangoes and cannabis. tell a friend

Myrcene Entourage Effect

If you mix myrcene isolate with a cannabinoid like CBD, you can boost the relaxing and anxiolytic (anti-anxiety) effects of both compounds. (15)

 

terpene anti-anxiety benefits

Myrcene helps your body uptake and make use of cannabinoids like CBD more effectively.

According to the study above, myrcene helps extend and intensify the health benefits of cannabinoids like CBD, CBN, and CBG. (16)

Myrcene doesn’t only increase the effectiveness of cannabinoids, it has health benefits of its own.

 

Myrcene helps extend and intensify the health benefits of cannabinoids like CBD, CBN, and CBG. tell a friend

 

Myrcene Health Benefits

Myrcene is especially good at relieving pain.

It has been used for centuries in traditional medicines around the world. (17)

myrcene cannabidiol therapy

Beyond pain relief, myrcene has anti-inflammatory and muscle relaxing properties too.

When present in high doses, myrcene may act as a powerful sedative. (18)

Myrcene isolate taken with CBN (cannabinol) may even have sedative effects comparable to valium.

anti-anxiety terpene mood benefits

Is myrcene the terpene that causes the sedative “couch-lock” effect in Indica strains of cannabis?

Some scientists think so… (19)

sedative effect

CBD and myrcene isolate taken together help fight anxiety even when you’re feeling your most anxious.

 

myrcene entourage effect

Taking myrcene isolate with CBN can be a powerful sleep-promoting combination too.

If you’ve had a particularly crushing day, you might try adding myrcene to your evening relaxation routine.

It could be a powerful aid to your rest and recovery.

Expect CBD oil mixed with myrcene to make you pleasantly ready for a restful evening.

 

Linalool Terpene

Does stress pile up on you like bricks?

CBD with the terpene linalool is a natural way to restore composure.

Linalool Smell and Taste

Linalool is a lavender-scented terpene found in herbs and CBD cannabis strains

the terpene linalool has a scent similar to lavender

Linalool is found in over 200 species of plants making it one the most abundant terpenes.

linalool properties

Some fruits and vegetables contain very high concentrations of linalool. 

Linalool is found in over 200 species of plants making it one of the most abundant terpenes. tell a friend

 

Linalool Traditional Medicine

Linalool has been used by people throughout history as a traditional medicine.

It is non-toxic to humans in common dosages though it can be an eye and skin irritant at very high concentrations. (20)

Within the body, linalool breaks down and is expelled quickly.

terpene adverse effects

Linalool has remarkable health benefits.

Its effects range from anti-anxiety results to anti-bacterial attributes. (21)

 

linalool health benefits

Linalool is used as a scenting agent in products like soap, shampoo, and skin care cream.

linalool uses

As with lavender, linalool has a natural sedative effect.

According to the study below, linalool is good for eliminating daily stress and anxiety. (22)

linalool anxiety benefits

Multiple studies have found that linalool is effective at fighting anxiety disorders such as Generalized Anxiety Disorder. (23)

linalool anxiety treatment

Linalool Cancer Benefits

Linalool boosts the immune system and has promising cancer-fighting effects.

Studies show linalool may help kill cancer cells and provide protection from tumors. (24)

linalool cancer benefits

Linalool Immune Booster

 

Linalool may boost your immune system by breaking down stress.

If struggling with stress is part of your daily routine then you know how it can negatively impact your immune system.

Not enough sleep and stress-induced inflammation are precursors to infection. (25)

terpene stress anxiety benefits

Linalool is also believed to affect the distribution of white blood cells.

White blood cells are your body’s immune system response to infection.

So, this terpene puts your immune system in a position to fight off infection before it occurs.

Linalool works with your body to more effectively use its own defenses.

More on this below.

 

Endocannabinoid System

‘Boosting your body’s own systems’ is a frequent theme with terpenes and CBD.

Fortifying your natural systems is central to CBD and terpenes benefits. (26)

 

linalool health benefits

CBD interacts with a vital regulatory system in your body.

That system is called the endocannabinoid system or ECS.

linalool cannabidiol benefits

Proper functioning of your endocannabinoid system is critical to your overall health.

terpene medical study nih

Terpenes and CBD together expand the effectiveness of your endocannabinoid system. (27)

Your body self-regulates constantly.

Sometimes it needs a little help.

That’s where CBD and terpenes come in.

Terpenes together with CBD restore balance.

They make your ECS work better so you feel better.

Terpenes and CBD together expand the effectiveness of your endocannabinoid system. tell a friend

Linalool Safety & Toxicity

Linalool side effects are few and toxicity is low.

It is considered a generally safe compound when used as a food additive according to the FDA. (28)

linalool adverse effects

 

Pinene Terpene

Do you enjoy cannabis?

Then it’s almost guaranteed that you’ve experienced the terpene pinene.

It’s very common in cannabis strains.

Smell And Taste

Pinene is responsible for the distinctive pine-like scent in cannabis strains.

the terpene pinene is responsible for the pine-like scent in cannabis

Does your cannabis smell a little bit like a pine forest?

That familiar pine scent in your cannabis is likely derived from the terpene pinene.

Cannabidiol terpene profile

Like other terpenes, pinene is found in many plant species.

Pinene is also found in orange peels, rosemary, dill, and basil.

You're just as likely to come across the terpene pinene in your favorite cannabis strain as you are in a daily diet of fresh leafy greens. tell a friend

 

Pinene Health Benefits

According to a 2017 study, pinene has significant anti-inflammatory properties.

It also has potential cancer-related benefits.

 

Pinene’s anti-inflammatory properties help relieve pain. (29)

pinene analgesic benefit

Mixing CBD with pinene makes the health benefits of each compound more effective. (30)

Here again, the potent entourage effect is at work for your benefit.

phytocannabinoid entourage effect

Together with full-spectrum CBD, pinene has stronger anti-inflammatory properties.

This is likely due to advantageous interactions with additional cannabinoids. (31)

CBD oil with pinene may act as a bronchodilator and open lung airways.

pinene health study

CBD mixtures high in pinene fight stress and anxiety in animal models. (32)

Pinene has significant benefits for hard to treat pain. (33)

terpene pain relief therapy

 

Pinene may have an anesthetic effect on hard to treat pain.

This effect is similar to that of the terpene caryophyllene.

pinene pain benefit

 

These known benefits are just the beginning.

Pinene is believed to have vast therapeutic potential. (34)

 

pinene health benefits

That’s quite a wide range of health benefits from one terpene.

Pinene is one of the best terpenes to look for.

Luckily, pinene is one of the most abundant terpenes in CBD cannabis strains.

A 2019 study calls pinene a “miracle” compound for its potential therapeutic benefits. (35)

 

 

Given Pinene’s list of benefits, that’s hard to argue with…

A 2019 medical study in the journal Biomolecules calls pinene a ‘miracle’ compound for its potential therapeutic benefits. Click To Tweet

Pinene Dosage

 

Cannabis strains with terpene profiles high in pinene will have different effects on different people.

Terpenes are consumed regularly in fruits and vegetables and believed to have minimal side effects when consumed as food.

pinene dosage safety

That said, it is recommended to start off slow.

See how pinene interacts with your specific body chemistry.

Then, increase or decrease your pinene dose as you feel appropriate.

Confused about CBD dosages?  There’s a CBD dosage guide right here.

pinene terpene dosage

Pinene Adverse Effects

 

Pinene has minimal side effects when consumed as food

There is some guidance on inhalation hazards but not in dose ranges you could expect to find in cannabis or hemp plant material.

These ranges mostly concern industrial applications. (36)

terpene adverse effects

 

Beta-Caryophyllene Terpene

Are you in pain?

Having difficulty finding something that takes away the pain but won’t get you hooked or loopy?

Does that sound like you?

Caryophyllene has some benefits you need to hear about.

Also known as Humulene, Caryophyllene is a terpene found in high CBD cannabis strains.

Caryophyllene is also found in spices like black pepper, hops, cloves, basil, and rosemary.

caryophyllene is a terpene found in cannabis and hops

Caryophyllene’s flavor is a bit spicy.

Its scent is similar to black pepper.

terpene caryophyllene description

Caryophyllene is one of the safest terpenes. (37)

It can be consumed in food in large quantities.

According to the FDA, caryophyllene is generally safe as a food additive.

 

The terpene caryophyllene's flavor is spicy with a scent similar to black pepper. tell a friend

 

Caryophyllene For Pain

 

Caryophyllene has many health benefits.

Taking caryophyllene for hard to treat pain is one of its main benefits. (38)

caryophyllene analgesic benefit

According to the 2013 study below, caryophyllene has significant pain-relieving properties. (39)

 

terpene medical study health benefits

 

Caryophyllene’s pain-relieving properties are increased when taken with cannabidiol (CBD). (40)

cannabidiol caryophyllene entourage

Caryophyllene For Inflammation

Caryophyllene also has significant anti-inflammatory properties.

Interestingly, its anti-inflammatory properties have been shown to protect the brain from premature aging in animal models. (41)

The 2019 study below says caryophyllene may be helpful for neurodegenerative conditions such as dementia and Alzheimer’s.

caryophyllene anti-inflammatory effects

Caryophyllene’s benefits result from its ability to activate the CB2 receptor.

The CB2 receptor is the same part of the endocannabinoid system (ECS).

The CB2 receptor is the same part of the nervous system that CBD activates.

Activation of the CB2 receptor may have benefits for treating multiple sclerosis as well. (42)

terpene health benefits

The endocannabinoid system is part of your larger nervous system.

It is present throughout your brain, spine, and extremities.

Caryophyllene, like CBD, functions as a signaling compound.

It relays regulatory signals throughout your endocannabinoid system.

Caryophyllene’s effect on your ECS can help maintain good health and homeostasis (chemical balance).

Interested in learning more about the endocannabinoid system? Click on the CBD guide below.


cannabidiol health benefits

The terpene caryophyllene can play a role in your body's ability to maintain good health and homeostasis. tell a friend

 

Caryophyllene Neuroprotective Effects

Caryophyllene may have benefits for Alzheimer’s and dementia. (43)

terpene health benefits

Its effects on dementia and Alzheimer’s disease result from its anti-inflammatory and antioxidant properties. (44)

terpene health study

 

More study is needed on human subjects to determine the extent of the benefit.

 

Caryophyllene For Addiction

 

Caryophyllene may help those with opioid dependence.

Caryophyllene increases the effects of low dose opiate painkillers. (45)

 

caryophyllene painkiller benefit

Individuals consuming opiates can take smaller doses of opiates but receive greater pain relief by adding caryophyllene.

Great pain relief from opiates in the presence of caryophyllene is a result of caryophyllene’s interaction with the CB2 receptor.

 

terpene analgesic benefit

 

Additionally, the anti-inflammatory benefits of caryophyllene may help gut and bowel disorders (such as IBS).

In animal studies of Colitis, caryophyllene reduced symptoms and sped recovery. (46)

 

caryophyllene IBD benefit

Caryophyllene Entourage Effect

Caryophyllene is frequently mentioned in connection with the terpene entourage effect.

The entourage effect maximizes terpene benefits and cannabinoid effects. (47)

Consumed together, caryophyllene and cannabinoids are believed to have a powerful synergistic effects.

The terpene entourage effect strengthens and lengthens the benefits of CBD and caryophyllene.

 

hemp entourage effect

 

Consume your CBD more efficiently: according to a 2019 study, dabbing CBD wax or rosin is the most efficient way to consume CBD.  See exactly how dabbing compares to smoking CBD flower here.

Caryophyllene Adverse Effects

Caryophyllene, like most terpenes, is recognized by the FDA as being a generally safe substance with minimal side effects when consumed as food.

terpene adverse effects

terpene adverse effects

 

And lastly, an interesting fact about caryophyllene…

caryophyllene fact

 

 

Terpinene Terpene

Terpinene is a terpene naturally found in CBD cannabis strains.

limonene smells similar to citrus and lemons

Terpinene isolate can also be derived from cardamom and marjoram oils.

terpene terpinene properties

Terpinene Smell And Taste

Terpinene is a colorless liquid that smells like turpentine.

It’s found infrequently in fruits and vegetables but is in multiple cannabis strains.

Terpinene has industrial applications where it’s used as a scenting and flavoring agent.

terpinene smell taste

 

Terpinene Health Benefits

According to a May 2019 study, terpinene has anti-bacterial and anti-microbial properties.

These properties make terpinene suitable for use in topical CBD creams.

Terpinene may have benefits for treating acne and atopic dermatitis topically. (48)

 

terpene skincare medical study

According to a 2018 study, terpinene has mild anxiety-causing effects when consumed in cannabis.  (49)

terpene anxiety chemovar

A 2018 survey of medical marijuana users reports strains with terpinene to have anxiety-causing effects.

terpene anxiety benefits

 

If you’re interested in CBD cannabis and its effects on anxiety, check out this CBD Anxiety Guide.

terpene medical research

 

A 2018 survey of medical marijuana users reports strains with terpinene to have anxiety-causing effects. tell a friend

 

Guaiol Terpene

Guaiol (pronounced “gweye-all”) is found in high CBD cannabis strains as well as Cypress Pine trees.

guaiol terpene characteristics

Guaiol Smell And Taste

Guaiol’s smell is similar to fresh pine with hints of rose.  

guaiol characteristics

It has a fruit-like flavor similar to red plums.  

limonene smells similar to citrus and lemons

Guaiol Health Benefits

Guaiol has anti-inflammatory effects and anti-bacterial properties. (50)

It’s a traditional medicine with a long history.

It has been used widely in Chinese medicine for centuries. 

guaiol antibiotic benefit

Historically, guaiol was used to treat diseases such as Gout, Arthritis, and the common sore throat.

 

Guaiol: Promising Cancer Benefits

The 2016 study below reports that guaiol may have anticancer benefits for non-small cell lung cancer. (51)

terpene lung cancer benefit

Guaiol may also relieve high blood pressure.

Unfortunately, there there is little scientific evidence to back up this historical claim.

 

Guaiol Anxiety Effects

According to a 2018 survey of medical cannabis patients, guaiol may increase anxiety (anxiogenic effect).

terpene anxiety effects

Interested in scientific studies on CBD and terpenes for anxiety?

Check out the latest medical evidence of CBD’s effects on anxiety.

guaiol anxiogenic effect

In a 2018 study, Guaiol was identified by medical marijuana patients as a terpene that potentially increases anxiety. (51)

terpene anxiety effects

According to a 2018 study, cannabis strains with the terpene guaiol may increase anxiety. tell a friend

Pain Relieving Effects

Interestingly, guaiol appears to have “anti-analgesic” effects.

This means guaiol may decrease the painkilling effects of CBD, cannabinoids, and other painkillers. (52)

terpene painkiller properties

The terpene guaiol may decrease the painkilling effects of CBD and cannabinoids. tell a friend

How strong is CBD’s painkilling effect? Learn here: CBD for Pain Relief.

guide to cannabidiol benefits for pain based on 2020 medical studies

 

Do you use CBD cream for pain?

Below you’ll find out how to make your CBD cream significantly more effective.

 

Trans-nerolidol Terpene

Are you getting the most from your CBD cream?

CBD topical products with trans-nerolidol increase the CBD absorption rate.

That means trans-nerolidol might make your cream more effective.

Trans-nerolidol helps CBD penetrate the skin.

terpene skin benefits

 

https://youtu.be/atxTojfhDr0

 

 

CBD topicals with trans-nerolidol increase the CBD absorption rate and could make CBD creams more effective. tell a friend

Smell And Taste

Trans-nerolidol is a secondary terpene found in some CBD cannabis strains.

It’s also found in jasmine, ginger, lavender, and tea-tree.

Trans-nerolidol has a fresh woody smell similar to tree bark.

terpene nerolidol properties

Trans-nerolidol has a fruit-like flavor similar to citrus.

 

Uses: Food Flavoring

Nerolidol is safe when consumed as a food flavoring agent and in cosmetics. (53)

 

terpene skin care

 

Health Benefits

Are you using a topical CBD product to help with pain?

Trans-nerolidol may help boost the pain-relieving benefits of your CBD cream.  

Trans-nerolidol has properties that help CBD penetrate the skin and get absorbed by the body. (54)

 

terpene skin benefits

Nerolidol can increase CBD skin penetration and dispersal of your cream’s active ingredients by up to 1956%.

terpene skincare benefits

Trans-nerolidol gives you a more efficient delivery of the active pain-relieving ingredients in CBD topicals.

That means the addition of a single terpene to your CBD cream may make all the ingredients more effective at fighting pain.

Additionally, trans-nerolidol has powerful anti-oxidant properties. (55)

 

terpene health benefits

Trans-nerolidol has anti-microbial benefits which may be helpful for certain skin conditions. (56)

terpene health benefits

Nerolidol has strong antifungal benefits.

Nerolidol fights both human and plant fungal diseases. (57)

terpene health study

Studies show trans-nerolidol has anti-cancer properties in animal models.

Nerolidol’s cancer-fighting properties have yet to be tested clinically in humans. (58)

terpene cancer benefits

More study is needed on the promising benefits of Nerolidol for specific cancers.

The terpene trans-nerolidol has powerful antioxidant, antimicrobial and antifungal properties which make it a good addition to your CBD topical cream. tell a friend

 

Bisabolol Terpene

Are you having difficulty getting to sleep?

Does anxiety keep you awake?

Try CBD tea with bisabolol.

It helps change your state of mind so you welcome sleep.

Bisabolol is not found in many plants but can be found in some CBD cannabis strains.

https://youtu.be/EQBycQWueiY

Bisabolol Smell and Taste

Bisabolol is the primary ingredient in essential oils from chamomile flowers.

 

limonene smells similar to citrus and lemons

Bisabolol has a weak flowery smell and a mildly sweet taste.

bisabolol terpene properties

 

Bisabolol Health Benefits

According to the 2014 study below, bisabolol has strong anti-inflammatory and anti-microbial properties.  (59)

terpene health benefits

Bisabolol may be useful in treating inflammatory skin conditions such as eczema and psoriasis. (60)

bisabolol health benefits

Bisabolol For Cosmetics

Bisabolol has been used in skincare remedies for centuries.

Recently, bisabolol anti-irritant and skin healing properties have found use in the cosmetics industry. (62)

bisabolol skincare benefits

Try a CBD cream with bisabolol isolate for the best results.

 

Bisabolol Adverse Effects

According to a 2013 study, in rare cases bisabolol has caused contact allergies while being used for skin inflammatory conditions.

terpene side effects allergy

 

 

Carene Terpene

Does arthritis cause you pain?

Find a CBD hemp strain high in carene.

https://youtu.be/vPazH7hTrMk

Delta 3 carene is found in some high CBD hemp strains.

It’s also found in cedar trees, pine trees, bell peppers, and basil.

 

 

limonene smells similar to citrus and lemons

Carene Smell And Taste

Carene has a piney taste with a slightly bitter aftertaste.

Carene has a sweet smell that is similar to wet woodlands and cypress trees.

carene terpene properties

Appealing scent, right?

 

 

Carene For Cosmetics

Delta 3 Carene is used in cosmetics.

It is believed to be a natural anti-histamine.

Carene has excellent anti-inflammatory properties according to medical studies. (61)

In the study below, carene was examined as a potential treatment for acute skin inflammation. (62)

terpene inflammation treatment

 

 

Carene Health Benefits

 

In animal models, Delta 3 Carene has shown significant bone healing abilities.  (63)

Carene is may be a good choice for those with osteoporosis and arthritis.

 

carene bone health

Delta 3 Carene has anti-inflammatory, antifungal, and antibacterial benefits. (64)

carene health benefits

Though yet to be fully understood, delta 3 carene helps with memory creation and memory retention.

Hopefully, carene may have an impact on future treatments for Alzheimer’s disease and dementia.

 

 

 

Eucalyptol Terpene

 

Eucalyptol, also known as cineole, is found in small quantities in CBD cannabis strains.

https://youtu.be/xgVUUR0tuAY

 

 

Eucalyptol Smell And Taste

Eucalyptol is clear and colorless.

It has a minty, slightly spicy smell and a cooling flavor.

eucalyptol properties

Eucalyptol is also found in sweet basil, bay leaves, wormwood, rosemary, and common sage.

eucalyptol sources

Eucalyptol is used as a scenting agent in cosmetics and fragrances.

It is also used to flavor baked goods.

 

limonene smells similar to citrus and lemons

Eucalyptol Health Benefits

Eucalyptol found in high CBD cannabis strains in very small quantities.

Even still, it may have medicinal benefits.

Eucalyptol has pain-relieving and anti-inflammatory properties. (65)

 

terpene pain relief

Additionally, eucalyptol (also known as 8-cineole) has been examined for:

  • gastroprotective effects
  • antimicrobial
  • antifungal
  • insecticidal properties  (65)

 

gastroprotective antimicrobial anti-fungal

Eucalyptol’s most significant health benefit may be its gastroprotective qualities. (66)

terpene ulcer benefit

That said, Eucalyptol makes up less than .06% of the complete terpene profile of most cannabis strains.

It’s known as a minor terpene.

 

 

Eucalyptol Adverse Effects

Although eucalyptol is used as a flavoring agent in baked goods, if ingested in larger quantities it can be toxic.

eucalyptol terpene toxicity

Interested in learning more about the safety and toxicity of eucalyptol? Click on the European Commission guide below.

 

 

Camphene Terpene

 

Camphene is a terpene found in CBD cannabis strains.

https://youtu.be/PAwzo5Md8Tc

 

 

Camphene Smell And Taste

Camphene has a damp woodland or musky earth smell.

camphene terpene properties

Camphene is used in essential oils like cypress oil, ginger oil, and citronella oil.

limonene smells similar to citrus and lemons

 

Camphene Health Benefits

Camphene has promising health benefits identified by medical studies.

Camphene may inhibit the growth of aggressive melanoma cancers. (67)

 

terpene skin benefits

Camphene has shown strong antioxidant effects that may have applications in lung inflammatory diseases where oxidative stress is critical.  (68)

camphene inflammation benefit

Applied in a CBD cream, Camphene may help inflammatory skin conditions such as psoriasis and eczema. (69)

terpene skin inflammation disease benefits

According to the 2016 study below, taken orally with a CBD tincture camphene lowers triglycerides and cholesterol.

terpene cardiovascular benefit

Since these factors contribute to heart disease, it is believed that camphene, may be a treatment for cardiovascular disease. (70)

terpene heart health

 

The terpene camphene may help inflammatory skin conditions such as psoriasis and eczema when applied topically. tell a friend

 

 

Borneol Terpene

 

Borneol is one of the most exciting terpenes.

Borneol has been used for more than a thousand years in traditional medicine.

borneol terpene history

New research says borneol may help compounds cross the blood-brain barrier.

 

https://youtu.be/cj2tPsJm0q8

 

Borneol Smell and Taste

Borneol is found in cannabis, mint, and rosemary

limonene smells similar to citrus and lemons

Borneol has a spicy, minty smell and flavor.

borneol properties

 

Borneol Uses

The borneol terpene found in cannabis may be used as an insect repellant.

Borneol repels ticks and mosquitoes.

borneol mosquito repellent

Borneol Health Benefits

Unfortunately, few peer-reviewed medical studies exist on the health benefits of borneol.

One study suggests that borneol (taken together with conventional cancer treatments) may aid in the treatment of specific types of ovarian cancer. (71)

 

terpene cancer benefit

Though it has been somewhat ignored by western medicine, borneol has been used in traditional Chinese medicine for more than 1500 years as a type of circulation aid.

borneol circulatory treatment

In a 2017 study, borneol was found to have benefits for aiding the delivery of drugs to the brain. (72)

 

borneol health benefits

So, it appears borneol has the ability to help drugs pass the “blood-brain barrier.”

This means borneol can help deliver a more effective dose of medicine to the brain while protecting it from disease. (73)

borneol health benefits

In acupuncture, borneol is considered to have a wide range of health benefits including:

  • digestive aid
  • help with heart function
  • aid in circulation.

The terpene borneol math help compounds like CBD cross the blood-brain barrier. tell a friend

 

Borneol Adverse Effects

Borneol isolate is an eye and skin irritant.

In our research, we have come across any reports of adverse effects from the modest levels of borneol present in cannabis.

terpene toxicity side effects

 

Terpineol Terpene

 

Terpineol may be the compound responsible for the ‘couch-lock effect.’

The couch-lock is a sedative effect usually associated with Indica strains of cannabis.

 

https://youtu.be/NlgUiIR5tnA

 

Terpineol is found in CBD cannabis strains and pine oil.

terpineol sources

 

Terpineol Smell and Taste

Terpineol is a colorless liquid with a floral scent similar to lilac flowers and apple blossom.

terpineol terpene properties

Terpineol has a sweet and slightly fruity flavor.

limonene smells similar to citrus and lemons

Terpineol for Relaxation

 

Terpineol has strong relaxing and sedation properties. (74)

 

terpineol insomnia benefit

Terpineol’s sedative effects are caused by its chemical structure.

Unlike the terpene linalool which derives its relaxing effect from its association with a pleasant odor, terpineol’s sedative effects result from the absorption of the compound into the bloodstream. (75)

terpineol relaxing benefit

 

Interested in experiencing the strongest relaxing effects from cannabinoids? Try pairing terpineol isolate with CBN (cannabinol).

CBN cannabinol benefits

Combining CBN (cannabinol) and terpineol isolate will have strong anti-anxiety and sleep-promoting effects.

 

Terpineol Health Benefits

Terpineol may inhibit the growth of tumors and cause tumor cell death in small cell lung carcinoma cancer. (76)

terpene cancer treatment

Terpineol has anti-inflammatory properties that may reduce pain and inflammatory diseases. (77)

 

terpineol health effects

Terpineol has powerful antifungal properties.

It may even be considered a natural food preservative for fresh fruits. (78)

terpene benefits terpineol

 

Interested in experiencing the strongest relaxing effects from cannabinoids? Try pairing terpineol isolate with CBN (cannabinol). tell a friend

 

 

 

Valencene Terpene

 

https://youtu.be/0hMyCjtleIE

 

Valencene Smell and Taste

Do you love cannabis strains with sweet fruit smell?

If your favorite CBD cannabis strains have a strong orange or tangerine smell and flavor, they’re likely high in the terpene valencene.

 

limonene smells similar to citrus and lemons

 

Valencene has a robust citrus smell and flavor.

 

valencene properties

As you may have guessed from the name of this terpene, valencene is found in high quantities in Valencia oranges.

valencene properties

 

 

Valencene Uses

Because of its appealing fragrance, the terpene valencene is used in cosmetics and perfumes.

Valencene isolate can act as an insect repellant for ticks and mosquitoes.

Studies show that valencene’s effectiveness is similar to deet, the active ingredient in most chemical insect repellents. (78)

 

valencene uses

Valencene is being studied for additional health benefits including anti-inflammatory and antimicrobial benefits.

Mix valencene into a CBD tincture and it may cause an entourage effect that boosts CBD’s anti-inflammatory properties.

valencene health benefits

Valencene has significant anti-microbial properties which may be useful in topical CBD creams.

 

 

Geraniol Terpene

Geraniol is a terpene found in CBD cannabis strains.

It’s a primary component in rose oil and citronella oil.

geraniol properties

https://youtu.be/wwflDI8xr68

 

Geraniol Smell And Taste

Geraniol is used in bath products for its appealing scent.

It has a fruity aroma similar to peaches and plums.

limonene smells similar to citrus and lemons

Geraniol has a mild fruity taste and is used as a flavoring agent.

geraniol terpene properties

It can also act as a sweet-smelling insect repellent for mosquitos.

geraniol uses

Interestingly, geraniol is produced by the scent glands of honey bees.

Honey bees use geraniol to mark the location of nectar-producing flowers and the entrance to hives.

 

 

Geraniol Health Benefits

 

Geraniol health benefits are significant and extensive.

Geraniol is a neuroprotectant with sedative effects.

Geraniol may help protect the brain from neurological disorders such as dementia or Alzheimer’s. (79)

 

geraniol health benefits

According to studies, the terpene geraniol may have benefits for treating specific cancers including:

  • breast
  • lung
  • colon
  • prostate
  • pancreatic
  • hepatic

geraniol cancer benefits

Geraniol is believed to be a “multi-target agent” against cancer.

Multi-target agents attack cancer cells in diverse ways.

The multitargeting approach to fighting cancer makes geraniol less susceptible to adaptive resistance by cancer cells. (80)

geraniol cancer treatment

In animal models, geraniol appears to have high antioxidant potential.

Geraniol has exceptional bioavailability when consumed orally. (81)

geraniol oral terpene

 

The terpene geraniol is believed to be a 'multi-target agent' against cancer. This makes geraniol more effective against adaptive resistance by cancer cells. tell a friend

 

Terpene Side Effects

 

Terpenes are generally regarded as having minimal side effects.

Terpenes are present in many wild plants and food crops.

It is likely that you are already consuming many cannabis terpenes daily.

You should expect that your regular fruit and vegetable diet will share some of the same terpenes with cannabis.

So, terpenes are nothing new to your body.

Taking CBD and terpene isolates together is new.

Proceed cautiously until you understand how your body will respond.

Everyone’s body is different.

Start off slowly with any new compounds.

Dial-in your CBD and terpene dosage as you go.

Check out this simple CBD dosage guide video by Dr. Liptan.  Many of the same principles will apply to terpenes.

https://www.youtube.com/watch?v=E98emmt63fs

Now that you know more about the best CBD terpenes, find what works for you.

Check back with this terpene from time to time.

It will be updated regularly as new health studies are published.

 

 

References

1. Nuutinen T. Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus. Eur J Med Chem. 2018;157:198–228. doi:10.1016/j.ejmech.2018.07.076

2. Russo EB. The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Front Plant Sci. 2019;9:1969. Published 2019 Jan 9. doi:10.3389/fpls.2018.01969

3. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x

4. Russo EB. The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Front Plant Sci. 2019;9:1969. Published 2019 Jan 9. doi:10.3389/fpls.2018.01969

5. Cho KS, Lim YR, Lee K, Lee J, Lee JH, Lee IS. Terpenes from Forests and Human Health. Toxicol Res. 2017;33(2):97–106. doi:10.5487/TR.2017.33.2.097

6. Russo EB. The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Front Plant Sci. 2019;9:1969. Published 2019 Jan 9. doi:10.3389/fpls.2018.01969

7.  Hoenen M, Müller K, Pause BM, Lübke KT. Fancy Citrus, Feel Good: Positive Judgment of Citrus Odor, but Not the Odor Itself, Is Associated with Elevated Mood during Experienced Helplessness. Front Psychol. 2016;7:74. Published 2016 Feb 2. doi:10.3389/fpsyg.2016.00074

8.  Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x

9.  Russo EB. The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Front Plant Sci. 2019;9:1969. Published 2019 Jan 9. doi:10.3389/fpls.2018.01969

10.  Russo EB. The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Front Plant Sci. 2019;9:1969. Published 2019 Jan 9. doi:10.3389/fpls.2018.01969

11-14. Sun J. D-Limonene: safety and clinical applications. Altern Med Rev. 2007;12(3):259–264.

  1. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  2. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  3. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  4. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  5. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  6. National Center for Biotechnology Information. PubChem Database. Linalool, CID=6549, https://pubchem.ncbi.nlm.nih.gov/compound/Linalool (accessed on Mar. 22, 2020)
  7. Malcolm BJ, Tallian K. Essential oil of lavender in anxiety disorders: Ready for prime time?. Ment Health Clin. 2018;7(4):147–155. Published 2018 Mar 26. doi:10.9740/mhc.2017.07.147
  8. Kamal BS, Kamal F, Lantela DE. Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype. Front Neurosci. 2018;12:730. Published 2018 Oct 22. doi:10.3389/fnins.2018.00730
  9. Malcolm BJ, Tallian K. Essential oil of lavender in anxiety disorders: Ready for prime time?. Ment Health Clin. 2018;7(4):147–155. Published 2018 Mar 26. doi:10.9740/mhc.2017.07.147
  10. Chang MY, Shen YL. Linalool exhibits cytotoxic effects by activating antitumor immunity. Molecules. 2014;19(5):6694–6706. Published 2014 May 22. doi:10.3390/molecules19056694
  11. Dhabhar FS. Effects of stress on immune function: the good, the bad, and the beautiful. Immunol Res. 2014;58(2-3):193–210. doi:10.1007/s12026-014-8517-0
  12. Fine PG, Rosenfeld MJ. The endocannabinoid system, cannabinoids, and pain. Rambam Maimonides Med J. 2013;4(4):e0022. Published 2013 Oct 29. doi:10.5041/RMMJ.10129
  13. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  14. Malcolm BJ, Tallian K. Essential oil of lavender in anxiety disorders: Ready for prime time?. Ment Health Clin. 2018;7(4):147–155. Published 2018 Mar 26. doi:10.9740/mhc.2017.07.147
  15. Cho KS, Lim YR, Lee K, Lee J, Lee JH, Lee IS. Terpenes from Forests and Human Health. Toxicol Res. 2017;33(2):97–106. doi:10.5487/TR.2017.33.2.097
  16. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  17. Russo EB. The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Front Plant Sci. 2019;9:1969. Published 2019 Jan 9. doi:10.3389/fpls.2018.01969
  18. Kasuya H, Iida S, Ono K, Satou T, Koike K. Intracerebral Distribution of a-Pinene and the Anxiolytic-like Effect in Mice Following Inhaled Administration of Essential Oil from Chamaecyparis obtuse. Nat Prod Commun. 2015;10(8):1479–1482.
  19. Russo EB. Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag. 2008;4(1):245–259. doi:10.2147/tcrm.s1928
  20. Salehi B, Upadhyay S, Erdogan Orhan I, et al. Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature. Biomolecules. 2019;9(11):738. Published 2019 Nov 14. doi:10.3390/biom9110738
  21. Salehi B, Upadhyay S, Erdogan Orhan I, et al. Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature. Biomolecules. 2019;9(11):738. Published 2019 Nov 14. doi:10.3390/biom9110738
  22. National Center for Biotechnology Information. PubChem Database. alpha-Pinene, CID=6654, https://pubchem.ncbi.nlm.nih.gov/compound/alpha-Pinene (accessed on Mar. 22, 2020)
  23. Schmitt D, Levy R, Carroll B. Toxicological Evaluation of β-Caryophyllene Oil: Subchronic Toxicity in Rats. Int J Toxicol. 2016;35(5):558–567. doi:10.1177/1091581816655303
  24. Fidyt K, Fiedorowicz A, Strządała L, Szumny A. β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties. Cancer Med. 2016;5(10):3007–3017. doi:10.1002/cam4.816
  25. Fine PG, Rosenfeld MJ. The endocannabinoid system, cannabinoids, and pain. Rambam Maimonides Med J. 2013;4(4):e0022. Published 2013 Oct 29. doi:10.5041/RMMJ.10129
  26. Fine PG, Rosenfeld MJ. The endocannabinoid system, cannabinoids, and pain. Rambam Maimonides Med J. 2013;4(4):e0022. Published 2013 Oct 29. doi:10.5041/RMMJ.10129
  27. Fine PG, Rosenfeld MJ. The endocannabinoid system, cannabinoids, and pain. Rambam Maimonides Med J. 2013;4(4):e0022. Published 2013 Oct 29. doi:10.5041/RMMJ.10129
  28. Alberti TB, Barbosa WL, Vieira JL, Raposo NR, Dutra RC. (-)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis. Int J Mol Sci. 2017;18(4):691. Published 2017 Apr 1. doi:10.3390/ijms18040691
  29. Machado KDC, Islam MT, Ali ES, et al. A systematic review on the neuroprotective perspectives of beta-caryophyllene. Phytother Res. 2018;32(12):2376–2388. doi:10.1002/ptr.6199
  30. Machado KDC, Islam MT, Ali ES, et al. A systematic review on the neuroprotective perspectives of beta-caryophyllene. Phytother Res. 2018;32(12):2376–2388. doi:10.1002/ptr.6199
  31. Katsuyama S, Mizoguchi H, Kuwahata H, et al. Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception. Eur J Pain. 2013;17(5):664–675. doi:10.1002/j.1532-2149.2012.00242.x
  32. Bento AF, Marcon R, Dutra RC, et al. β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway. Am J Pathol. 2011;178(3):1153–1166. doi:10.1016/j.ajpath.2010.11.052
  33. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x
  34. Wróblewska A, Retajczyk M, Kądziołka D, Markowska-Szczupak A. Microbiological Tests of Natural Limonene and the Compounds Obtained after Isomerization of Limonene in the Presence of Ti-SBA-15 Catalyst-α-Terpinene, γ-Terpinene, Terpinolene, and p-Cymene. J Cosmet Sci. 2019;70(3):137–147.
  35. Kamal BS, Kamal F, Lantela DE. Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype. Front Neurosci. 2018;12:730. Published 2018 Oct 22. doi:10.3389/fnins.2018.00730
  36. Yang Q, Wu J, Luo Y, et al. (-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer. Oncotarget. 2016;7(38):62585–62597. doi:10.18632/oncotarget.11540
  37. Yang Q, Wu J, Luo Y, et al. (-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer. Oncotarget. 2016;7(38):62585–62597. doi:10.18632/oncotarget.11540
  38. Kamal BS, Kamal F, Lantela DE. Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype. Front Neurosci. 2018;12:730. Published 2018 Oct 22. doi:10.3389/fnins.2018.00730
  39. Chan WK, Tan LT, Chan KG, Lee LH, Goh BH. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016;21(5):529. Published 2016 Apr 28. doi:10.3390/molecules21050529
  40. Chan WK, Tan LT, Chan KG, Lee LH, Goh BH. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016;21(5):529. Published 2016 Apr 28. doi:10.3390/molecules21050529
  41. Vinholes J, Gonçalves P, Martel F, Coimbra MA, Rocha SM. Assessment of the antioxidant and antiproliferative effects of sesquiterpenic compounds in in vitro Caco-2 cell models. Food Chem. 2014;156:204–211. doi:10.1016/j.foodchem.2014.01.106
  42. Chan WK, Tan LT, Chan KG, Lee LH, Goh BH. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016;21(5):529. Published 2016 Apr 28. doi:10.3390/molecules21050529
  43. Chan WK, Tan LT, Chan KG, Lee LH, Goh BH. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016;21(5):529. Published 2016 Apr 28. doi:10.3390/molecules21050529
  44. Chan WK, Tan LT, Chan KG, Lee LH, Goh BH. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016;21(5):529. Published 2016 Apr 28. doi:10.3390/molecules21050529
  45. Maurya AK, Singh M, Dubey V, Srivastava S, Luqman S, Bawankule DU. α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. Curr Pharm Biotechnol. 2014;15(2):173–181. doi:10.2174/1389201015666140528152946
  46. Maurya AK, Singh M, Dubey V, Srivastava S, Luqman S, Bawankule DU. α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. Curr Pharm Biotechnol. 2014;15(2):173–181. doi:10.2174/1389201015666140528152946
  47. Ocete MA, Risco S, Zarzuelo A, Jimenez J. Pharmacological activity of the essential oil of Bupleurum gibraltaricum: anti-inflammatory activity and effects on isolated rat uteri. J Ethnopharmacol. 1989;25(3):305–313. doi:10.1016/0378-8741(89)90036-6
  48. Gil ML, Jimenez J, Ocete MA, Zarzuelo A, Cabo MM. Comparative study of different essential oils of Bupleurum gibraltaricum Lamarck. Pharmazie. 1989;44(4):284–287.
  49. Jeong JG, Kim YS, Min YK, Kim SH. Low concentration of 3-carene stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Phytother Res. 2008;22(1):18–22. doi:10.1002/ptr.2247
  50. Jeong JG, Kim YS, Min YK, Kim SH. Low concentration of 3-carene stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Phytother Res. 2008;22(1):18–22. doi:10.1002/ptr.2247
  51. Caceres AI, Liu B, Jabba SV, Achanta S, Morris JB, Jordt SE. Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. Br J Pharmacol. 2017;174(9):867–879. doi:10.1111/bph.13760
  52. Caceres AI, Liu B, Jabba SV, Achanta S, Morris JB, Jordt SE. Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. Br J Pharmacol. 2017;174(9):867–879. doi:10.1111/bph.13760
  53. Girola N, Figueiredo CR, Farias CF, et al. Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo. Biochem Biophys Res Commun. 2015;467(4):928–934. doi:10.1016/j.bbrc.2015.10.041
  54. Tiwari M, Kakkar P. Plant derived antioxidants – Geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol In Vitro. 2009;23(2):295–301. doi:10.1016/j.tiv.2008.12.014
  55. Orchard A, van Vuuren S. Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases. Evid Based Complement Alternat Med. 2017;2017:4517971. doi:10.1155/2017/4517971
  56. Vallianou I, Peroulis N, Pantazis P, Hadzopoulou-Cladaras M. Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. PLoS One. 2011;6(11):e20516. doi:10.1371/journal.pone.0020516
  57. Zou L, Wang D, Hu Y, et al. Drug resistance reversal in ovarian cancer cells of paclitaxel and borneol combination therapy mediated by PEG-PAMAM nanoparticles. Oncotarget. 2017;8(36):60453–60468. Published 2017 Jul 31. doi:10.18632/oncotarget.19728
  58. Zhang QL, Fu BM, Zhang ZJ. Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood-brain barrier permeability. Drug Deliv. 2017;24(1):1037–1044. doi:10.1080/10717544.2017.1346002
  59. Zhang QL, Fu BM, Zhang ZJ. Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood-brain barrier permeability. Drug Deliv. 2017;24(1):1037–1044. doi:10.1080/10717544.2017.1346002
  60. Ito K, Ito M. Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds. J Nat Med. 2011;65(2):336–343. doi:10.1007/s11418-010-0502-x
  61. Ito K, Ito M. Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds. J Nat Med. 2011;65(2):336–343. doi:10.1007/s11418-010-0502-x
  62. Hassan SB, Gali-Muhtasib H, Göransson H, Larsson R. Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling. Anticancer Res. 2010;30(6):1911–1919.
  63. de Oliveira MG, Marques RB, de Santana MF, et al. α-terpineol reduces mechanical hypernociception and inflammatory response. Basic Clin Pharmacol Toxicol. 2012;111(2):120–125. doi:10.1111/j.1742-7843.2012.00875.x
  64. Dietrich G, Dolan MC, Peralta-Cruz J, et al. Repellent activity of fractioned compounds from Chamaecyparis nootkatensis essential oil against nymphal Ixodes scapularis (Acari: Ixodidae). J Med Entomol. 2006;43(5):957–961. doi:10.1603/0022-2585(2006)43[957:raofcf]2.0.co;2
  65. Ayaz M, Sadiq A, Junaid M, Ullah F, Subhan F, Ahmed J. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants. Front Aging Neurosci. 2017;9:168. Published 2017 May 30. doi:10.3389/fnagi.2017.00168
  66. Cho M, So I, Chun JN, Jeon JH. The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review). Int J Oncol. 2016;48(5):1772–1782. doi:10.3892/ijo.2016.3427
  67. Pavan B, Dalpiaz A, Marani L, et al. Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes. Front Pharmacol. 2018;9:18. Published 2018 Jan 25. doi:10.3389/fphar.2018.00018

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